PVT1: A long non-coding RNA recurrently involved in neoplasia-associated fusion transcripts

被引：18

作者：

Tolomeo, Doron ^{[1
]}

Agostini, Antonio ^{[2
]}

Visci, Grazia ^{[1
]}

Traversa, Debora ^{[1
]}

Storlazzi, Clelia Tiziana ^{[1
]}

机构：

[1] Univ Bari, Dept Biol, Via Orabona 4, I-70125 Bari, Italy

[2] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Unit Internal Med Guido Baccelli, Piazza Giulio Cesare 11, I-70124 Bari, Italy

来源：

GENE | 2021年 / 779卷

关键词：

Fusion transcript; PVT1; MYC; Amplification; Trans-splicing;

D O I：

10.1016/j.gene.2021.145497

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

NGS technologies and bioinformatics tools allow the rapid identification of chimeric transcripts in cancer. More than 40,000 fusions are so far reported in the literature; however, for most of them, the role in oncogenesis is still not fully understood. This is the case for fusions involving the long non-coding RNA (lncRNA) Plasmacytoma variant translocation 1 (PVT1) (8q24.21). This lncRNA displays oncogenic functions in several cancer types interacting with microRNAs and proteins, but the role of PVT1 fusion transcripts is more obscure. These chimeras have been identified in both hematological malignancies and solid tumors, mainly arising from rearrangements and/or amplification of the 8q24 chromosomal region. In this review, we detail the full spectrum of PVT1 fusions in cancer, summarizing current knowledge about their genesis, function, and role as biomarkers.

引用

页数：11

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