Donor origin CAR T cells: graft versus malignancy effect without GVHD, a systematic review

被引：79

作者：

Anwer, Faiz ^{[1
,2
]}

Shaukat, Al-Aman ^{[3
]}

Zahid, Umar ^{[4
,5
]}

Husnain, Muhammad ^{[4
]}

McBride, Ali ^{[6
]}

Persky, Daniel ^{[1
,2
]}

Lim, Melissa ^{[2
]}

Hasan, Nida ^{[7
]}

Bin Riaz, Irbaz

机构：

[1] Univ Arizona, Dept Med Hematol & Oncol, Tucson, AZ 85721 USA

[2] Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85721 USA

[3] James Paget Univ Hosp, Great Yarmouth, Norfolk, England

[4] Univ Arizona, Dept Med, Tucson, AZ USA

[5] Univ Arizona, Coll Publ Hlth, Tucson, AZ USA

[6] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA

[7] Univ Arizona, Zuckerman Coll Publ Hlth, Tucson, AZ USA

来源：

IMMUNOTHERAPY | 2017年 / 9卷 / 02期

基金：

美国国家卫生研究院;

关键词：

allogenic stem cell transplantation; chimeric antigen T cells; hematological; malignancy; graft versus leukemia; relapse; salvage; LEUKOCYTE INFUSIONS; ACUTE-LEUKEMIA; TRANSPLANTATION; OUTCOMES; RELAPSE; REMISSIONS;

D O I：

10.2217/imt-2016-0127

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD19, CD20 chimeric antigen receptor T (CAR T) cell therapy has shown promising results for the treatment of relapsed or refractory hematological malignancies. Best results have been reported in acute lymphoblastic leukemia patients with a complete response rate above 80%. Patients who received donor-derived CAR T cells for the relapsed malignancy after stem cell transplantation (allogenic hematopoietic stem cell transplant) were identified from the published trials. A total of 72 patients from seven studies were treated with donor-derived CAR T cells. Only five out of 72 patients (6.9%) developed graft versus host disease. Use of donor-derived CAR T cell for relapse prophylaxis, minimal residual disease clearance or salvage from relapse is therefore highly effective, and risk of graft versus host disease flare is very low. Side effects include cytokine release syndrome, tumor lysis syndrome, B-cell aplasia along with CNS toxicity.

引用

页码：123 / 130

页数：8

共 30 条

[1] Blinatumomab-induced donor T-cell activation for post-stem cell transplant-relapsed acute CD19-positive biphenotypic leukemia [J].

Alcharakh, Mohammed ;

Yun, Seongseok ;

Dong, Yimin ;

Vincelette, Nicole D. ;

Daud, Madiha ;

Manzoor, Saima ;

Bin Riaz, Irbaz ;

Anwer, Faiz .

IMMUNOTHERAPY, 2016, 8 (08) :847-852

[2]

[Anonymous], 2015, BLOOD

[3]

[Anonymous], 2015, BLOOD, DOI DOI 10.1182/BLOOD.V126.23.684.684

[4] Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy [J].

Bhoj, Vijay G. ;

Arhontoulis, Dimitrios ;

Wertheim, Gerald ;

Capobianchi, James ;

Callahan, Colleen A. ;

Ellebrecht, Christoph T. ;

Obstfeld, Amrom E. ;

Lacey, Simon F. ;

Melenhorst, Jan J. ;

Nazimuddin, Farzana ;

Hwang, Wei-Ting ;

Maude, Shannon L. ;

Wasik, Mariusz A. ;

Bagg, Adam ;

Schuster, Stephen ;

Feldman, Michael D. ;

Porter, David L. ;

Grupp, Stephen A. ;

June, Carl H. ;

Milone, Michael C. .

BLOOD, 2016, 128 (03) :360-370

[5]

Brentjens RJ, 2011, ASCO ANN M P S, V29, P2534

[6] Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease [J].

Brudno, Jennifer N. ;

Somerville, Robert P. T. ;

Shi, Victoria ;

Rose, Jeremy J. ;

Halverson, David C. ;

Fowler, Daniel H. ;

Gea-Banacloche, Juan C. ;

Pavletic, Steven Z. ;

Hickstein, Dennis D. ;

Lu, Tangying L. ;

Feldman, Steven A. ;

Iwamoto, Alexander T. ;

Kurlander, Roger ;

Maric, Irina ;

Goy, Andre ;

Hansen, Brenna G. ;

Wilder, Jennifer S. ;

Blacklock-Schuver, Bazetta ;

Hakim, Frances T. ;

Rosenberg, Steven A. ;

Gress, Ronald E. ;

Kochenderfer, James N. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (10) :1112-+

[7] Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation [J].

Collins, RH ;

Shpilberg, O ;

Drobyski, WR ;

Porter, DL ;

Giralt, S ;

Champlin, R ;

Goodman, SA ;

Wolff, SN ;

Hu, W ;

Verfaillie, C ;

List, A ;

Dalton, W ;

Ognoskie, N ;

Chetrit, A ;

Antin, JH ;

Nemunaitis, J .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (02) :433-444

[8] Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study [J].

Cruz, Conrad Russell Y. ;

Micklethwaite, Kenneth P. ;

Savoldo, Barbara ;

Ramos, Carlos A. ;

Lam, Sharon ;

Ku, Stephanie ;

Diouf, Oumar ;

Liu, Enli ;

Barrett, A. John ;

Ito, Sawa ;

Shpall, Elizabeth J. ;

Krance, Robert A. ;

Kamble, Rammurti T. ;

Carrum, George ;

Hosing, Chitra M. ;

Gee, Adrian P. ;

Mei, Zhuyong ;

Grilley, Bambi J. ;

Heslop, Helen E. ;

Rooney, Cliona M. ;

Brenner, Malcolm K. ;

Bollard, Catherine M. ;

Dotti, Gianpietro .

BLOOD, 2013, 122 (17) :2965-2973

[9] Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia [J].

Dai, Hanren ;

Zhang, Wenying ;

Li, Xiaolei ;

Han, Qingwang ;

Guo, Yelei ;

Zhang, Yajing ;

Wang, Yao ;

Wang, Chunmeng ;

Shi, Fengxia ;

Zhang, Yan ;

Chen, Meixia ;

Feng, Kaichao ;

Wang, Quanshun ;

Zhu, Hongli ;

Fu, Xiaobing ;

Li, Suxia ;

Han, Weidong .

ONCOIMMUNOLOGY, 2015, 4 (11)

[10] Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia [J].

Davila, Marco L. ;

Riviere, Isabelle ;

Wang, Xiuyan ;

Bartido, Shirley ;

Park, Jae ;

Curran, Kevin ;

Chung, Stephen S. ;

Stefanski, Jolanta ;

Borquez-Ojeda, Oriana ;

Olszewska, Malgorzata ;

Qu, Jinrong ;

Wasielewska, Teresa ;

He, Qing ;

Fink, Mitsu ;

Shinglot, Himaly ;

Youssif, Maher ;

Satter, Mark ;

Wang, Yongzeng ;

Hosey, James ;

Quintanilla, Hilda ;

Halton, Elizabeth ;

Bernal, Yvette ;

Bouhassira, Diana C. G. ;

Arcila, Maria E. ;

Gonen, Mithat ;

Roboz, Gail J. ;

Maslak, Peter ;

Douer, Dan ;

Frattini, Mark G. ;

Giralt, Sergio ;

Sadelain, Michel ;

Brentjens, Renier .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

← 1 2 3 →