Healthcare-associated Viral Gastroenteritis among Children in a Large Pediatric Hospital, United Kingdom

被引：74

作者：

Cunliffe, Nigel A. ^{[1
,2
]}

Booth, J. Angela

Elliot, Claire ^{[2
,3
]}

Lowe, Sharon J. ^{[2
]}

Sopwith, Will ^{[3
]}

Kitchin, Nick ^{[4
]}

Nakagomi, Osamu ^{[5
]}

Nakagomi, Toyoko ^{[5
]}

Hart, C. Anthony ^{[2
]}

Regan, Martyn ^{[3
]}

机构：

[1] Univ Liverpool, Div Med Microbiol, Liverpool L69 3GA, Merseyside, England

[2] Royal Liverpool Childrens Natl Hlth Serv Fdn Trus, Liverpool, Merseyside, England

[3] Hlth Protect Agcy NW, Liverpool, Merseyside, England

[4] Sanofi Pasteur MSD, Maidenhead, Berks, England

[5] Nagasaki Univ, Global Ctr Excellence Program, Nagasaki 852, Japan

来源：

EMERGING INFECTIOUS DISEASES | 2010年 / 16卷 / 01期

关键词：

INFECTIOUS INTESTINAL DISEASE; ROTAVIRUS GASTROENTERITIS; STRUCTURED SURVEILLANCE; DIARRHEA; VIRUSES; NOROVIRUSES; EXCRETION; COMMUNITY; VACCINES; STRAINS;

D O I：

10.3201/eid1601.090401

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viruses are the major pathogens of community-acquired (CA) acute gastroenteritis (AGE) in children, but their role in healthcare-associated (HA) AGE is poorly understood. Children with AGE hospitalized at Alder Hey Children's Hospital, Liverpool, UK, were enrolled over a 2-year period. AGE was classified as HA if diarrhea developed >= 48 hours after admission. Rotavirus, norovirus, adenovirus 40/41, astrovirus, and sapovirus were detected by PCR. A total of 225 children with HA-AGE and 351 with CA-AGE were enrolled in the study. HA viral gastroenteritis constituted one fifth of the diarrheal diseases among hospitalized children and commonly occurred in critical care areas. We detected >= 1 virus in 120 (53%) of HA-AGE cases; rotavirus (31%), norovirus (16%), and adenovirus 40/41 (15%) were the predominant viruses identified. Molecular evidence indicated rotaviruses and noroviruses were frequently introduced into the hospital from the community. Rotavirus vaccines could substantially reduce the incidence of HA-AGE in children.

引用

页码：55 / 62

页数：8

共 36 条

[1] Detection by PCR of eight groups of enteric pathogens in 4,627 faecal samples: re-examination of the English case-control Infectious Intestinal Disease Study (1993-1996) [J].