Synthesis of certain substituted quinoxalines as antimicrobial agents (part II)

被引：114

作者：

Badran, MM

Abouzid, KAM ^{[1
]}

Hussein, MHM

机构：

[1] Ain Shams Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo 11566, Egypt

[2] Cairo Univ, Fac Pharm, Dept Organ Chem, Cairo, Egypt

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2003年 / 26卷 / 02期

关键词：

ditriazoloquinoxalines; triazoloquinoxalines; triazoloquinoxalinethione; synthesis; antibacterial agents;

D O I：

10.1007/BF02976653

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several fused triazolo and ditriazoloquinoxaline derivatives such as 1-aryl-4-chloro-[1,2,4]triazolo[4,3-a]quinoxalines (3a-d), 4-alkoxy[1,2,4]triazolo[4,3-a]quinoxalines (4a,b), 4-substituted-amino-[1,2,4] triazolo[4,3-a]quinoxalines (5a-h), 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)thione (6), 4-(arylidenehydrazino)-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalines (10a-e) and [1,2,4]ditriazolo[4,3-a:3',4'-c]quinoxaline derivatives (11-13) have been synthesized and some of these derivatives were evaluated for antimicrobial and antifungal activity in vitro. It was found that compounds 3a and 9b possess potent antibacterial activity compared to the standard tetracycline.

引用

页码：107 / 113

页数：7

共 18 条

[1]

Badr MZA, 1997, J INDIAN CHEM SOC, V74, P30

[2] SOME 4-ALKYL S-TRIAZOLO[4,3-A]QUINOXALINES [J].