Synthesis of certain substituted quinoxalines as antimicrobial agents (part II)

被引：114
作者：
Badran, MM
Abouzid, KAM [1 ]
Hussein, MHM
机构：
[1] Ain Shams Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo 11566, Egypt
[2] Cairo Univ, Fac Pharm, Dept Organ Chem, Cairo, Egypt
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2003年 / 26卷 / 02期
关键词：
ditriazoloquinoxalines; triazoloquinoxalines; triazoloquinoxalinethione; synthesis; antibacterial agents;
D O I：
10.1007/BF02976653
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several fused triazolo and ditriazoloquinoxaline derivatives such as 1-aryl-4-chloro-[1,2,4]triazolo[4,3-a]quinoxalines (3a-d), 4-alkoxy[1,2,4]triazolo[4,3-a]quinoxalines (4a,b), 4-substituted-amino-[1,2,4] triazolo[4,3-a]quinoxalines (5a-h), 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)thione (6), 4-(arylidenehydrazino)-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalines (10a-e) and [1,2,4]ditriazolo[4,3-a:3',4'-c]quinoxaline derivatives (11-13) have been synthesized and some of these derivatives were evaluated for antimicrobial and antifungal activity in vitro. It was found that compounds 3a and 9b possess potent antibacterial activity compared to the standard tetracycline.
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页码：107 / 113
页数：7
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