Microwave-irradiated and classical syntheses of symmetric double Schiff bases of 1,1'-bis(4-aminophenyl)cyclohexane and their physicochemical characterization

A series of new symmetric double Schiff bases of 1, 1'-bis(4-aminophenyl)cyclohexane and substituted aromatic benzaldehyde are synthesized by classical and microwave-irradiated techniques. The synthesis time is much shorter and yields of the Schiff bases are found to be better with the microwave-irradiation technique than classical technique. The purity of Schiff bases is checked by TLC. The structures of Schiff bases are supported by FTIR, H-1 NMR, and MS techniques. The biological activity of Schiff bases is checked against Gram-positive and Gram-negative microbes. Schiff bases showed moderate antibacterial activity but showed moderate to excellent antifungal activity in comparison with chosen standard drugs.