Robustness and efficiency in inverse protein folding

被引：6
|
作者：
Fink, TM
Ball, RC
机构：
[1] Theory of Condensed Matter, Cavendish Laboratory
来源：
PHYSICA D | 1997年 / 107卷 / 2-4期
基金：
美国国家科学基金会;
关键词：
inverse protein folding; protein design; protein folding;
D O I：
10.1016/S0167-2789(97)00087-0
中图分类号：
O29 [应用数学];
学科分类号：
070104 ;
摘要：
Successful protein design is characterized by two criteria: thermodynamic robustness, the probability of occupation of the target conformation, and kinetic efficiency, the ability of the protein to quickly fold to its target state. We observe a conflict between robustness and efficiency upon variation of both the pair potential matrix and the designed sequence. We argue that marginal reduction in thermodynamic robustness can provide significant increase in kinetic efficiency, thereby allowing improved protein design.
引用
收藏
页码：199 / 203
页数：5
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