Dual plasmonic gold nanostars for photoacoustic imaging and photothermal therapy

被引：33
作者：
Raghavan, Vijay [1 ]
O'Flatharta, Cathal [2 ]
Dwyer, Roisin [3 ]
Breathnach, Aedan [4 ]
Zafar, Haroon [4 ]
Dockery, Peter [5 ]
Wheatley, Antony [6 ]
Keogh, Ivan [7 ]
Leahy, Martin [4 ,8 ,9 ]
Olivo, Malini [1 ,10 ]
机构：
[1] Natl Univ Ireland Galway, Sch Phys, Galway, Ireland
[2] Natl Univ Ireland, Sch Med, Regenerat Med Inst REMEDI, Galway, Ireland
[3] Natl Univ Ireland Galway, Lambe Inst Translat Res, Discipline Surg, Galway, Ireland
[4] Natl Univ Ireland, Tissue Opt & Microcirculat Imaging Facil, Galway, Ireland
[5] Natl Univ Ireland, Anat, Galway, Ireland
[6] Natl Univ Ireland, Physiol, Galway, Ireland
[7] Natl Univ Ireland, Dept Surg, Galway, Ireland
[8] Royal Coll Surg RCSI, Dublin, Ireland
[9] Natl Biophoton & Imaging Platform, Dublin, Ireland
[10] Agcy Sci Technol & Res, Singapore Bioimaging Consortium, Bioopt Imaging Grp, Singapore, Singapore
来源：
NANOMEDICINE | 2017年 / 12卷 / 05期
基金：
爱尔兰科学基金会;
关键词：
gold nanostar; near infrared imaging; optical window; photoacoustic imaging; photothermal therapy; plasmonic nanoparticles; silica shell; surface plasmon resonance; OPTICAL-PROPERTIES; NANOPARTICLES; NANORODS; CANCER; SPECTROSCOPY; SCATTERING; SYSTEM;
D O I：
10.2217/nnm-2016-0318
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To fabricate multimodal nanoconstruct that act as a single node for photoacoustic imaging (PAI) and photothermal therapy (PTT) in the fight against cancer. Materials & methods: Dual plasmonic gold nanostars (DPGNS) were chemically synthesized by reducing gold precursor using ascorbic acid and silver ions as shape directing agent. PAI and PTT were performed using commonly available 1064 nm laser source on DPGNS embedded tumor xenografts on mice. Results & conclusion: Photoacoustic amplitude increase with longer wavelength source and with silica coating of DPGNS. The in vivo photothermal capability of DPGNS resulted in a significant decrease in the tumor cellular area. DPGNS exhibited potential for single node diagnosis and therapy with longer wavelength facilitating deeper imaging and therapy.
引用
收藏
页码：457 / 471
页数：15
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