LC 16m8: An attenuated smallpox vaccine

被引：130

作者：

Kenner, Julie

Cameron, Fiona

Empig, Cyril

Jobes, David V.

Gurwith, Marc

机构：

[1] VaxGen, Inc.

来源：

VACCINE | 2006年 / 24卷 / 47-48期

关键词：

LC; 16m8; lister; smallpox; vaccinia; vaccine; bioterrorism; orthopoxvirus;

D O I：

10.1016/j.vaccine.2006.03.087

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The frequency of moderate to severe adverse reactions associated with smallpox vaccines currently stockpiled in the US, and the continued threat of bioterrorism have prompted the development of effective vaccines with improved safety profiles. LC16m8, an attenuated, replicating smallpox vaccine derived from the Lister strain of vaccinia, is currently licensed in Japan where it was safely used in over 50,000 children in the 1970s. It has been shown to have markedly less neurotoxicity than unattenuated vaccines in nonclinical studies. LC16m8 is immunogenic after a single dose, and recent studies in two different animal models have demonstrated protective efficacy equivalent to that of the only FDA-licensed smallpox vaccine. This article reviews the history and available scientific literature regarding LC16m8 and provides comparisons to other smallpox vaccines. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：7009 / 7022

页数：14

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