Dupilumab and alopecia: A Janus effect

被引：28

作者：

Patruno, Cataldo ^{[1
]}

Napolitano, Maddalena ^{[2
]}

Ferrillo, Maria ^{[3
]}

Fabbrocini, Gabriella ^{[3
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy

[2] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, Campobasso, Italy

[3] Univ Naples Federico II, Dept Clin Med & Surg, Sect Dermatol, Naples, Italy

来源：

DERMATOLOGIC THERAPY | 2019年 / 32卷 / 05期

关键词：

adult atopic dermatitis; alopecia areata; drug reaction; dupilumab; paradox reaction;

D O I：

10.1111/dth.13023

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) and alopecia areata (AA) are two common skin diseases that can coexist in the same patient, sharing some pathogenetic mechanisms such as the overexpression of interleukin 4 (IL4) and interleukin 13 (IL13). Recently, cases of AA healing during treatment with anti-IL4/IL13 monoclonal antibody dupilumab (D) for AD were reported. However, cases of appearance of AA have been described during D treatment too. We report two patients that experienced these two opposite effects of D.

引用

页数：4

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