Treatment of the primary in metastatic prostate cancer

被引：5

作者：

Gingu, Constantin ^{[1
,2
]}

Heidenreich, Axel ^{[3
]}

Andresanu, Andrei ^{[1
]}

Mihancea, Adrian ^{[1
]}

Sinescu, Ioanel ^{[1
,2
]}

Baston, Catalin ^{[1
,2
]}

机构：

[1] Fundeni Clin Inst, Ctr Uronephrol & Renal Transplantat, 258 Fundeni Ave,2nd Dist, Bucharest 022328, Romania

[2] Carol Davila Univ Med & Pharm Bucharest, Bucharest, Romania

[3] Univ Klinikum, Cologne, Germany

来源：

CURRENT OPINION IN UROLOGY | 2020年 / 30卷 / 04期

关键词：

cytoreductive prostatectomy; metastases-directed therapy; oligometastatic; prostate cancer; radiotherapy; ANDROGEN-DEPRIVATION THERAPY; RADICAL PROSTATECTOMY; DIRECTED THERAPY; LOCAL THERAPY; CYTOREDUCTIVE PROSTATECTOMY; BODY RADIOTHERAPY; PRIMARY TUMOR; CONTROL ARM; HIGH-RISK; SURVIVAL;

D O I：

10.1097/MOU.0000000000000779

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review The standard treatment in metastatic prostate cancer (mPCa) is systemic, based on androgen deprivation therapy recommended in different forms, alone or combined with abiraterone acetate or docetaxel. The aim of this review is to synthesize the available data from literature regarding the optimal treatment of the primary in patients diagnosed with metastatic prostate cancer. Recent findings Multimodal treatments offer the best chance for survival for these patients, but the optimal strategy lacks consensus. Using retrospective studies as an argument, recent articles sustain the clinical and oncological benefits of local therapies in hormone-naive metastatic prostate cancer, represented by radical prostatectomy or radiotherapy. Through these procedures, local control of disease can be achieved, thus avoiding potential complications and further surgical interventions. Even if the current results are not evenly relevant, the treatment of the primary along with metastasis-directed therapy could improve survival and even cure-selected patients. Summary This article emphasizes important aspects regarding a feasible management of mPCa, with possible impact on subsequent guidelines. The expected results from ongoing trials may provide another perspective in treatment of these cases.

引用

页码：566 / 575

页数：10

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