Treatment of the primary in metastatic prostate cancer

被引:5
作者
Gingu, Constantin [1 ,2 ]
Heidenreich, Axel [3 ]
Andresanu, Andrei [1 ]
Mihancea, Adrian [1 ]
Sinescu, Ioanel [1 ,2 ]
Baston, Catalin [1 ,2 ]
机构
[1] Fundeni Clin Inst, Ctr Uronephrol & Renal Transplantat, 258 Fundeni Ave,2nd Dist, Bucharest 022328, Romania
[2] Carol Davila Univ Med & Pharm Bucharest, Bucharest, Romania
[3] Univ Klinikum, Cologne, Germany
关键词
cytoreductive prostatectomy; metastases-directed therapy; oligometastatic; prostate cancer; radiotherapy; ANDROGEN-DEPRIVATION THERAPY; RADICAL PROSTATECTOMY; DIRECTED THERAPY; LOCAL THERAPY; CYTOREDUCTIVE PROSTATECTOMY; BODY RADIOTHERAPY; PRIMARY TUMOR; CONTROL ARM; HIGH-RISK; SURVIVAL;
D O I
10.1097/MOU.0000000000000779
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review The standard treatment in metastatic prostate cancer (mPCa) is systemic, based on androgen deprivation therapy recommended in different forms, alone or combined with abiraterone acetate or docetaxel. The aim of this review is to synthesize the available data from literature regarding the optimal treatment of the primary in patients diagnosed with metastatic prostate cancer. Recent findings Multimodal treatments offer the best chance for survival for these patients, but the optimal strategy lacks consensus. Using retrospective studies as an argument, recent articles sustain the clinical and oncological benefits of local therapies in hormone-naive metastatic prostate cancer, represented by radical prostatectomy or radiotherapy. Through these procedures, local control of disease can be achieved, thus avoiding potential complications and further surgical interventions. Even if the current results are not evenly relevant, the treatment of the primary along with metastasis-directed therapy could improve survival and even cure-selected patients. Summary This article emphasizes important aspects regarding a feasible management of mPCa, with possible impact on subsequent guidelines. The expected results from ongoing trials may provide another perspective in treatment of these cases.
引用
收藏
页码:566 / 575
页数:10
相关论文
共 80 条
[1]   Impact of Adjuvant Radiotherapy on Survival of Patients With Node-Positive Prostate Cancer [J].
Abdollah, Firas ;
Karnes, R. Jeffrey ;
Suardi, Nazareno ;
Cozzarini, Cesare ;
Gandaglia, Giorgio ;
Fossati, Nicola ;
Vizziello, Damiano ;
Sun, Maxine ;
Karakiewicz, Pierre I. ;
Menon, Mani ;
Montorsi, Francesco ;
Briganti, Alberto .
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (35) :3939-U222
[2]  
Ahmed KA, 2012, FRONT ONCOL, V2, DOI [10.3389/fonc.2012.00215, 10.3389/fonc.2012.00172]
[3]   Innovations in imaging modalities for recurrent and metastatic prostate cancer: a systematic review [J].
Albisinni, Simone ;
Aoun, Fouad ;
Marcelis, Quentin ;
Jungels, Claude ;
Obeid, Walid Al-Hajj ;
Zanaty, Marc ;
Tubaro, Andrea ;
Roumeguere, Thierry ;
De Nunzio, Cosimo .
MINERVA UROLOGICA E NEFROLOGICA, 2018, 70 (04) :347-360
[4]   Prognostic impact of definitive local therapy of the primary tumor in men with metastatic prostate cancer at diagnosis: A population-based, propensity score analysis [J].
Antwi, Samuel ;
Everson, Todd M. .
CANCER EPIDEMIOLOGY, 2014, 38 (04) :435-441
[5]   "Hit the primary": A paradigm shift in the treatment of metastatic prostate cancer? [J].
Arcangeli, Stefano ;
Zilli, Thomas ;
De Bari, Berardino ;
Alongi, Filippo .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2016, 97 :231-237
[6]   Salvage Stereotactic Body Radiotherapy for Patients With Limited Prostate Cancer Metastases: Deferring Androgen Deprivation Therapy [J].
Berkovic, Patrick ;
De Meerleer, Gert ;
Delrue, Louke ;
Lambert, Bieke ;
Fonteyne, Valerie ;
Lumen, Nicolaas ;
Decaestecker, Karel ;
Villeirs, Geert ;
Vuye, Philippe ;
Ost, Piet .
CLINICAL GENITOURINARY CANCER, 2013, 11 (01) :27-32
[7]   Effect on Overall Survival of Locoregional Treatment in a Cohort of De Novo Metastatic Prostate Cancer Patients: A Single Institution Retrospective Analysis From the Royal Marsden Hospital [J].
Bianchini, Diletta ;
Lorente, David ;
Rescigno, Pasquale ;
Zafeiriou, Zafeiris ;
Psychopaida, Elena ;
O'Sullivan, Hazel ;
Alaras, Mervyn ;
Kolinsky, Michael ;
Sumanasuriya, Semini ;
Fontes, Mariane Sousa ;
Mateo, Joaquin ;
Lopez, Raquel Perez ;
Tunariu, Nina ;
Fotiadis, Nikolaos ;
Kumar, Pardeep ;
Tree, Alison ;
Van As, Nicholas ;
Khoo, Vincent ;
Parker, Chris ;
Eeles, Rosalind ;
Thompson, Alan ;
Dearnaley, David ;
de Bono, Johann S. .
CLINICAL GENITOURINARY CANCER, 2017, 15 (05) :E801-E807
[8]  
Boevé LMS, 2019, EUR UROL, V75, P410, DOI 10.1016/j.eururo.2018.09.008
[9]   Combination of Adjuvant Hormonal and Radiation Therapy Significantly Prolongs Survival of Patients With pT2-4 pN+ Prostate Cancer: Results of a Matched Analysis [J].
Briganti, Alberto ;
Karnes, R. Jeffrey ;
Da Pozzo, Luigi Filippo ;
Cozzarini, Cesare ;
Capitanio, Umberto ;
Gallina, Andrea ;
Suardi, Nazareno ;
Bianchi, Marco ;
Tutolo, Manuela ;
Salonia, Andrea ;
Di Muzio, Nadia ;
Rigatti, Patrizio ;
Montorsi, Francesco ;
Blute, Michael .
EUROPEAN UROLOGY, 2011, 59 (05) :832-840
[10]   Prostate Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis [J].
Burdett, Sarah ;
Boeve, Liselotte M. ;
Ingleby, Fiona C. ;
Fisher, David J. ;
Rydzewska, Larysa H. ;
Vale, Claire L. ;
van Andel, George ;
Clarke, Noel W. ;
Hulshof, Maarten C. ;
James, Nicholas D. ;
Parker, Christopher C. ;
Parmar, Mahesh K. ;
Sweeney, Christopher J. ;
Sydes, Matthew R. ;
Tombal, Bertrand ;
Verhagen, Paul C. ;
Tierney, Jayne F. .
EUROPEAN UROLOGY, 2019, 76 (01) :115-124