Psychosocial Assessment of Candidates for Transplant (PACT) as a tool for psychological and social evaluation of allogeneic hematopoietic cell transplantation recipients

被引:20
作者
Hong, Sanghee [1 ]
Rybicki, Lisa [2 ]
Corrigan, Donna [3 ]
Dabney, Jane [3 ]
Hamilton, Betty K. [3 ,4 ]
Kalaycio, Matt [3 ,4 ]
Lawrence, Christine [3 ]
McLellan, Linda [3 ]
Sobecks, Ronald [3 ,4 ]
Lee, Stephanie J. [1 ]
Majhail, Navneet S. [3 ,4 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA
[2] Cleveland Clin, Dept Quantitat Hlth Sci, Cleveland, OH 44106 USA
[3] Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA
[4] Cleveland Clin, Dept Hematol & Oncol, Cleveland, OH 44106 USA
关键词
BONE-MARROW-TRANSPLANTATION; QUALITY-OF-LIFE; RATING-SCALE; SURVIVAL; ASSOCIATION; OUTCOMES; DEPRESSION; VARIABLES; DISTRESS; TIME;
D O I
10.1038/s41409-019-0455-y
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Psychosocial Assessment of Candidates for Transplant (PACT) is a tool originally developed to address psychosocial risks in solid organ transplant recipients and has the potential for application to hematopoietic cell transplantation (HCT) recipients. In a retrospective cohort study, we reviewed 404 adult allogeneic HCT cases from 2003 to 2014 to identify predictors of adverse psychosocial status as determined by PACT. Final PACT rating was poor/borderline (score 0-1) in 5%, acceptable (score 2) in 22%, good (score 3) in 44%, and excellent (score 4) in 29% recipients. In multivariable regression, higher PACT score was associated with White race (odds ratio [OR] 2.95, P < 0.001), having a related donor (OR 1.61, P = 0.015), and a higher quality of life score (OR 1.22/10-point increase in FACT-BMT total score, P < 0.001). PACT score correlated with all quality of life subscales. The final PACT score was associated with non-relapse mortality (HR 0.82/ 1-point increase, p = 0.03) in multivariable analysis that considered patient and disease factors, but not in models that also included transplant-related factors and performance status. PACT score was not associated with overall survival. PACT can be considered as part of a comprehensive psychosocial assessment for identifying patients who may require additional resources around allogeneic HCT.
引用
收藏
页码:1443 / 1452
页数:10
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