Psychosocial Assessment of Candidates for Transplant (PACT) as a tool for psychological and social evaluation of allogeneic hematopoietic cell transplantation recipients

被引:19
作者
Hong, Sanghee [1 ]
Rybicki, Lisa [2 ]
Corrigan, Donna [3 ]
Dabney, Jane [3 ]
Hamilton, Betty K. [3 ,4 ]
Kalaycio, Matt [3 ,4 ]
Lawrence, Christine [3 ]
McLellan, Linda [3 ]
Sobecks, Ronald [3 ,4 ]
Lee, Stephanie J. [1 ]
Majhail, Navneet S. [3 ,4 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA
[2] Cleveland Clin, Dept Quantitat Hlth Sci, Cleveland, OH 44106 USA
[3] Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA
[4] Cleveland Clin, Dept Hematol & Oncol, Cleveland, OH 44106 USA
关键词
BONE-MARROW-TRANSPLANTATION; QUALITY-OF-LIFE; RATING-SCALE; SURVIVAL; ASSOCIATION; OUTCOMES; DEPRESSION; VARIABLES; DISTRESS; TIME;
D O I
10.1038/s41409-019-0455-y
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Psychosocial Assessment of Candidates for Transplant (PACT) is a tool originally developed to address psychosocial risks in solid organ transplant recipients and has the potential for application to hematopoietic cell transplantation (HCT) recipients. In a retrospective cohort study, we reviewed 404 adult allogeneic HCT cases from 2003 to 2014 to identify predictors of adverse psychosocial status as determined by PACT. Final PACT rating was poor/borderline (score 0-1) in 5%, acceptable (score 2) in 22%, good (score 3) in 44%, and excellent (score 4) in 29% recipients. In multivariable regression, higher PACT score was associated with White race (odds ratio [OR] 2.95, P < 0.001), having a related donor (OR 1.61, P = 0.015), and a higher quality of life score (OR 1.22/10-point increase in FACT-BMT total score, P < 0.001). PACT score correlated with all quality of life subscales. The final PACT score was associated with non-relapse mortality (HR 0.82/ 1-point increase, p = 0.03) in multivariable analysis that considered patient and disease factors, but not in models that also included transplant-related factors and performance status. PACT score was not associated with overall survival. PACT can be considered as part of a comprehensive psychosocial assessment for identifying patients who may require additional resources around allogeneic HCT.
引用
收藏
页码:1443 / 1452
页数:10
相关论文
共 50 条
  • [21] Objective and subjective physical function in allogeneic hematopoietic stem cell transplant recipients
    Mishra, Asmita
    Pidala, Joseph
    Thapa, Ram
    Betts, Brian C.
    Fernandez, Hugo
    Locke, Frederick L.
    Nishihori, Taiga
    Perez, Lia
    Wang, Xuefeng
    Anasetti, Claudio
    Jim, Heather
    BONE MARROW TRANSPLANTATION, 2021, 56 (12) : 2897 - 2903
  • [22] Risk factors for invasive mold diseases in allogeneic hematopoietic cell transplant recipients
    Atalla, A.
    Garnica, M.
    Maiolino, A.
    Nucci, M.
    TRANSPLANT INFECTIOUS DISEASE, 2015, 17 (01) : 7 - 13
  • [23] Comparison of Outcomes After Second Allogeneic Hematopoietic Cell Transplantation Versus Donor Lymphocyte Infusion in Allogeneic Hematopoietic Cell Transplant
    Al-Shaibani, Eshrak
    Bautista, Rhida
    Lipton, Jeffrey H.
    Kim, Dennis D.
    Viswabandya, Auro
    Kumar, Rajat
    Lam, Wilson
    Law, Arjun D.
    Al-Shaibani, Zeyad
    Gerbitz, Armin
    Pasic, Ivan
    Mattsson, Jonas
    Michelis, Fotios, V
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 (05) : E327 - E334
  • [24] Standard of Care for Psychological Assessment of Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
    Trigiani, Brooke E.
    Polek, Carolee
    CLINICAL JOURNAL OF ONCOLOGY NURSING, 2024, 28 (01) : 71 - 78
  • [25] Outcomes in Critically Ill Allogeneic Hematopoietic Stem-Cell Transplantation Recipients
    Lafarge, Antoine
    Dupont, Thibault
    Canet, Emmanuel
    Moreau, Anne-Sophie
    Picard, Muriel
    Mokart, Djamel
    Platon, Laura
    Mayaux, Julien
    Wallet, Florent
    Issa, Nahema
    Raphalen, Jean-Herle
    Pene, Frederic
    Renault, Anne
    de la Tour, Regis Peffault
    Recher, Christian
    Chevallier, Patrice
    Zafrani, Lara
    Darmon, Michael
    Bige, Naike
    Azoulay, Elie
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 210 (08) : 1017 - 1024
  • [26] Allogeneic Hematopoietic Stem Cell Transplantation in Solid Organ Transplant Recipients: A Retrospective, Multicenter Study of the EBMT
    Basak, G. W.
    Wiktor-Jedrzejczak, W.
    Labopin, M.
    Schoemans, H.
    Ljungman, P.
    Kobbe, G.
    Beguin, Y.
    Lang, P.
    Koenecke, C.
    Sykora, K. W.
    te Boome, L.
    van Biezen, A.
    van der Werf, S.
    Mohty, M.
    de Witte, T.
    Marsh, J.
    Dreger, P.
    Kroeger, N.
    Duarte, R.
    Ruutu, T.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15 (03) : 705 - 714
  • [27] Psychological states and needs among post-allogeneic hematopoietic stem cell transplantation survivors
    Sun, Yanling
    Yan, Pu
    Xu, Duorong
    Zhong, Zhiyong
    Xu, Ting
    Xin, Wenjun
    Zhang, Xiangzhong
    Zhang, Jingwen
    CANCER MEDICINE, 2023, 12 (15): : 16637 - 16648
  • [28] Impact of pre-transplant depression on outcomes of allogeneic and autologous hematopoietic stem cell transplantation
    El-Jawahri, Areej
    Chen, Yi-Bin
    Brazauskas, Ruta
    He, Naya
    Lee, Stephanie J.
    Knight, Jennifer M.
    Majhail, Navneet
    Buchbinder, David
    Schears, Raquel M.
    Wirk, Baldeep M.
    Wood, William A.
    Ahmed, Ibrahim
    Aljurf, Mahmoud
    Szer, Jeff
    Beattie, Sara M.
    Battiwalla, Minoo
    Dandoy, Christopher
    Diaz, Miguel-Angel
    D'Souza, Anita
    Freytes, Cesar O.
    Gajewski, James
    Gergis, Usama
    Hashmi, Shahrukh K.
    Jakubowski, Ann
    Kamble, Rammurti T.
    Kindwall-Keller, Tamila
    Lazarus, Hilard M.
    Malone, Adriana K.
    Marks, David I.
    Meehan, Kenneth
    Savani, Bipin N.
    Olsson, Richard F.
    Rizzieri, David
    Steinberg, Amir
    Speckhart, Dawn
    Szwajcer, David
    Schoemans, Helene
    Seo, Sachiko
    Ustun, Celalettin
    Atsuta, Yoshiko
    Dalal, Jignesh
    Sales-Bonfim, Carmem
    Khera, Nandita
    Hahn, Theresa
    Saber, Wael
    CANCER, 2017, 123 (10) : 1828 - 1838
  • [29] The Role of Age in Neurocognitive Functioning among Adult Allogeneic Hematopoietic Cell Transplant Recipients
    Hoogland, Aasha I.
    Nelson, Ashley M.
    Small, Brent J.
    Hyland, Kelly A.
    Gonzalez, Brian D.
    Booth-Jones, Margaret
    Anasetti, Claudio
    Jacobsen, Paul B.
    Jim, Heather S. L.
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (11) : 1974 - 1979
  • [30] Risk factors for hemorrhagic cystitis in pediatric allogeneic hematopoietic stem cell transplant recipients
    Hayden, R. T.
    Gu, Z.
    Liu, W.
    Lovins, R.
    Kasow, K.
    Woodard, P.
    Srivastava, K.
    Leung, W.
    TRANSPLANT INFECTIOUS DISEASE, 2015, 17 (02) : 234 - 241