Microwave-Assisted Synthesis and Evaluation of Antimicrobial Activity of 3-{3-(s-Aryl and s-Heteroaromatic)acryloyl}-2H-chromen-2-one Derivatives

被引：68
|
作者：
Ajani, Olayinka O. [1 ]
Nwinyi, Obinna C. [2 ]
机构：
[1] Covenant Univ, Coll Sci & Technol, Dept Chem, Ota, Ogun State, Nigeria
[2] Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 47卷 / 01期
关键词：
ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; COUMARIN; CHALCONE;
D O I：
10.1002/jhet.298
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3-acetylcoumarin (1) with aromatic and heteroaromatic aldehydes to afford the corresponding aromatic chalcones (2a-j) and heteroaromatic chalcones (3a-e and 4a-e), respectively, in good to excellent yield within 1-3 min. The chemical structures were confirmed by analytical and spectral data. All the synthesized compounds were screened for their antibacterial activity and 3-{3-(4-dimethylaminophenyl)acryloyl}-2H-chromen-2-one (2i) was discovered to be the most active at minimum inhibitory concentration (MIC) value of 7.8 mu g/mL.
引用
收藏
页码：179 / 187
页数：9
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