Microwave-Assisted Synthesis and Evaluation of Antimicrobial Activity of 3-{3-(s-Aryl and s-Heteroaromatic)acryloyl}-2H-chromen-2-one Derivatives

被引：68

作者：

Ajani, Olayinka O. ^{[1
]}

Nwinyi, Obinna C. ^{[2
]}

机构：

[1] Covenant Univ, Coll Sci & Technol, Dept Chem, Ota, Ogun State, Nigeria

[2] Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 47卷 / 01期

关键词：

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; COUMARIN; CHALCONE;

D O I：

10.1002/jhet.298

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3-acetylcoumarin (1) with aromatic and heteroaromatic aldehydes to afford the corresponding aromatic chalcones (2a-j) and heteroaromatic chalcones (3a-e and 4a-e), respectively, in good to excellent yield within 1-3 min. The chemical structures were confirmed by analytical and spectral data. All the synthesized compounds were screened for their antibacterial activity and 3-{3-(4-dimethylaminophenyl)acryloyl}-2H-chromen-2-one (2i) was discovered to be the most active at minimum inhibitory concentration (MIC) value of 7.8 mu g/mL.

引用

页码：179 / 187

页数：9

共 50 条

[1] SYNTHESIS AND ANTIOXIDANT ACTIVITY OF (E)-3-(3-(4-OXO-4H-CHROMEN-3-YL)ACRYLOYL) 2H-CHROMEN-2-ONE DERIVATIVES
Shatokhin, S. S.
Tuskaev, V. A.
Gagieva, S. Ch
Pozdnyakov, D., I
Oganesyan, E. T.
PHARMACY & PHARMACOLOGY-FARMATSIYA I FARMAKOLOGIYA, 2021, 9 (05): : 367 - 376
[2] (E)-3-[3-(4-Morpholinophenyl)acryloyl]-2H-chromen-2-one
Suwito, Hery
Hardiyanti, Helda Dwi
Ul Haq, Kautsar
Kristanti, Alfinda Novi
Khasanah, Miratul
MOLBANK, 2018, (04)
[3] Cesium-Doped Tungstophosphoric Acid: An Efficient, Recyclable Catalyst for the Synthesis of 3-(3-(Substituted aryl/heteroaryl)acryloyl)-2H-chromen-2-one Derivatives in Water
Bakht, Md Afroz
Alotaibi, Mshari A.
Alharthi, Abdulrahman, I
Din, Israf Ud
Ahsan, Mohamed Jawed
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2021, 31 (04) : 553 - 559
[4] One-pot Synthesis of Novel 3-(Aryl(heteroarylamino)methyl)-2H-chromen-2-one Derivatives
Olyaei, Abolfazl
Dortaj, Elham
Khoeiniha, Reyhaneh
Rajabi, Fatemeh
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (12) : 2971 - 2976
[5] Microwave-Assisted Synthesis and Antimicrobial Activity of 3-(Arylsulfanyl)-4-hydroxy-2H-chromen-2-ones
Ch. Anjaiah
M. Nagamani
Ch. Abraham Lincoln
D. Ashok
Russian Journal of General Chemistry, 2018, 88 : 2149 - 2153
[6] Microwave-Assisted Synthesis and Antimicrobial Activity of 3-(Arylsulfanyl)-4-hydroxy-2H-chromen-2-ones
Anjaiah, Ch.
Nagamani, M.
Lincoln, Ch. Abraham
Ashok, D.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (10) : 2149 - 2153
[7] Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
Kakkar, Saloni
Kumar, Sanjiv
Lim, Siong Meng
Ramasamy, Kalavathy
Mani, Vasudevan
Shah, Syed Adnan Ali
Narasimhan, Balasubramanian
CHEMISTRY CENTRAL JOURNAL, 2018, 12
[8] Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
Saloni Kakkar
Sanjiv Kumar
Siong Meng Lim
Kalavathy Ramasamy
Vasudevan Mani
Syed Adnan Ali Shah
Balasubramanian Narasimhan
Chemistry Central Journal, 12
[9] 3-[2-(Triphenylphosphanylidene) acetyl]-2H-chromen-2-one
Taha, Muhammad
Ismail, Nor Hadiani
Aziza, Ahmad Nazif
Shah, Syed Adnan Ali
Yousuf, Sammer
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O245 - +
[10] Synthesis and antibacterial activity of a new series of 3-[3-(substituted phenyl)-1-phenyl-1H-pyrazol-5-yl]-2H-chromen-2-one derivatives
Aragade, Prashant
Narayanan, R. Venkat
Maddi, Veeresh
Patil, Pankaj
Shinde, Prashant
Agrawal, Mohan
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2012, 27 (06) : 849 - 853

← 1 2 3 4 5 →