Expression and role of retinoic acid receptor alpha in lens regeneration

被引：0
|
作者：
Tsonis, PA [1 ]
Tsavaris, M
Call, MK
Chandraratna, RAS
Del Rio-Tsonis, K
机构：
[1] Univ Dayton, Dept Biol, Mol Biol Lab, Dayton, OH 45469 USA
[2] Allergan Pharmaceut Inc, Retinoid Res, Dept Chem, Irvine, CA 92623 USA
[3] Allergan Pharmaceut Inc, Retinoid Res, Dept Biol, Irvine, CA 92623 USA
[4] Miami Univ, Dept Zool, Oxford, OH 45056 USA
来源：
DEVELOPMENT GROWTH & DIFFERENTIATION | 2002年 / 44卷 / 05期
关键词：
lens; regeneration; retinoic acid receptor alpha;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The role of retinoids in eye development has been well studied. Retinoids and their receptors regulate gene expression and morphogenesis of the eye. In this study, a highly specific antagonist of retinoic acid receptor (RAR)-alpha was used in an attempt to study its function in lens regeneration. It was found that this antagonist inhibited lens regeneration and lens fiber differentiation. It was also shown that RAR-alpha is expressed in the lens during the process of regeneration. These results indicate that different RAR might have unique as well as redundant effects and patterns of expression in the regenerating lens.
引用
收藏
页码：391 / 394
页数：4
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