Expression and role of retinoic acid receptor alpha in lens regeneration

被引：0
|
作者：
Tsonis, PA [1 ]
Tsavaris, M
Call, MK
Chandraratna, RAS
Del Rio-Tsonis, K
机构：
[1] Univ Dayton, Dept Biol, Mol Biol Lab, Dayton, OH 45469 USA
[2] Allergan Pharmaceut Inc, Retinoid Res, Dept Chem, Irvine, CA 92623 USA
[3] Allergan Pharmaceut Inc, Retinoid Res, Dept Biol, Irvine, CA 92623 USA
[4] Miami Univ, Dept Zool, Oxford, OH 45056 USA
来源：
DEVELOPMENT GROWTH & DIFFERENTIATION | 2002年 / 44卷 / 05期
关键词：
lens; regeneration; retinoic acid receptor alpha;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The role of retinoids in eye development has been well studied. Retinoids and their receptors regulate gene expression and morphogenesis of the eye. In this study, a highly specific antagonist of retinoic acid receptor (RAR)-alpha was used in an attempt to study its function in lens regeneration. It was found that this antagonist inhibited lens regeneration and lens fiber differentiation. It was also shown that RAR-alpha is expressed in the lens during the process of regeneration. These results indicate that different RAR might have unique as well as redundant effects and patterns of expression in the regenerating lens.
引用
收藏
页码：391 / 394
页数：4
相关论文
共 50 条
  • [1] Role of retinoic acid in lens regeneration
    Tsonis, PA
    Trombley, MT
    Rowland, T
    Chandraratna, RAS
    Del Rio-Tsonis, K
    DEVELOPMENTAL DYNAMICS, 2000, 219 (04) : 588 - 593
  • [2] Immunohistochemical analysis of retinoic acid receptor-alpha in human breast tumors - Retinoic acid receptor-alpha expression correlates with proliferative activity
    vanderLeede, BJM
    Geertzema, J
    Vroom, TM
    Decimo, D
    Lutz, Y
    vanderSaag, PT
    vanderBurg, B
    AMERICAN JOURNAL OF PATHOLOGY, 1996, 148 (06): : 1905 - 1914
  • [3] Retinoic acid modulates retinoid X receptor alpha and retinoic acid receptor alpha levels of cultured brown adipocytes
    Bonet, ML
    Puigserver, P
    Serra, F
    Ribot, J
    Vazquez, F
    Pico, C
    Palou, A
    FEBS LETTERS, 1997, 406 (1-2) : 196 - 200
  • [4] Differential role of homologous positively charged amino acid residues for ligand binding in retinoic acid receptor alpha compared with retinoic acid receptor beta
    Scafonas, A
    Wolfgang, CL
    Gabriel, JL
    Soprano, KJ
    Soprano, DR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (17) : 11244 - 11249
  • [5] Retinoic Acid Receptor Alpha Amplifications and Retinoic Acid Sensitivity in Breast Cancers
    Alsafadi, Samar
    Even, Caroline
    Falet, Coralie
    Goubar, Aicha
    Commo, Frederic
    Scott, Veronique
    Quidville, Virginie
    Albiges, Laurence
    Dieci, Maria-Vittoria
    Guegan, Justine
    Lazar, Vladimir
    Ahomadegbe, Jean-Charles
    Delaloge, Suzette
    Andre, Fabrice
    CLINICAL BREAST CANCER, 2013, 13 (05) : 401 - 408
  • [6] EXPRESSION OF A RETINOIC ACID RECEPTOR GENE IS REGULATED BY RETINOIC ACID ITSELF
    不详
    NUTRITION REVIEWS, 1990, 48 (09) : 355 - 357
  • [7] Photoaging and expression of retinoic acid receptor α
    Tsoureli-Nikita, E
    Watson, RE
    Bowden, JJ
    Griffiths, CE
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 122 (03) : A44 - A44
  • [8] alpha-Retinoic acid receptor antagonists
    Terrett, N
    DRUG DISCOVERY TODAY, 1997, 2 (11) : 501 - 502
  • [9] RETINOIC ACID PROMOTES PROLIFERATION AND INDUCES EXPRESSION OF RETINOIC ACID RECEPTOR-ALPHA GENE IN MURINE T-LYMPHOCYTES
    FRIEDMAN, A
    HALEVY, O
    SCHRIFT, M
    ARAZI, Y
    SKLAN, D
    CELLULAR IMMUNOLOGY, 1993, 152 (01) : 240 - 248
  • [10] RETINOIC ACID UP-REGULATES NUCLEAR RETINOIC ACID RECEPTOR-ALPHA EXPRESSION IN HUMAN NEUROBLASTOMA-CELLS
    WUARIN, L
    CHANG, B
    WADA, R
    SIDELL, N
    INTERNATIONAL JOURNAL OF CANCER, 1994, 56 (06) : 840 - 845
12345