Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency

被引：5
作者：
Pan, Xing-hua [1 ,2 ,3 ]
Zhou, Jing [1 ,2 ,3 ]
Yao, Xiang [1 ,2 ,3 ]
Shu, Jun [1 ,2 ,3 ]
Liu, Ju-fen [1 ,2 ,3 ]
Yang, Jian-yong [1 ,2 ,3 ]
Pang, Rong-qing [1 ,2 ,3 ]
Ruan, Guang-ping [1 ,2 ,3 ]
机构：
[1] Kunming Gen Hosp Peoples Liberat Army, Cell Biol Therapy Ctr, Kunming, Yunnan Province, Peoples R China
[2] Stem Cells & Immune Cells Biomed Tech Integrated, Kunming, Yunnan Province, Peoples R China
[3] Cell Therapy Technol Transfer Med Key Lab Yunnan, Kunming, Yunnan Province, Peoples R China
来源：
PLOS ONE | 2017年 / 12卷 / 04期
关键词：
ENDOTHELIAL PROGENITOR CELLS; CHRONIC KIDNEY-DISEASE; STROMAL CELLS; FAILURE; FIBROSIS; DIFFERENTIATION; INJURY; MODEL;
D O I：
10.1371/journal.pone.0176273
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Discovering a new cell transplantation approach for treating chronic renal insufficiency is a goal of many nephrologists. In vitro-cultured peripheral blood mononuclear cells (PBMCs) were reprogrammed into induced mesenchymal stem cells (iMSCs) by using natural inducing agents made in our laboratory. The stem cell phenotype of the iMSCs was then identified. Unilateral ureteral obstruction (UUO) was used to create an animal model of chronic renal insufficiency characterized by renal interstitial fibrosis. The induced and non-induced PBMCs were transplanted, and the efficacy of iMSCs in treating chronic renal insufficiency was evaluated using a variety of methods. The ultimate goal was to explore the effects of iMSC transplantation on the treatment of chronic renal insufficiency, with the aim of providing a new therapeutic modality for this disease.
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页数：14
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