BSA/Silver Nanoparticle-Loaded Hydrogel Film for Local Photothermal Treatment of Skin Cancer

被引：26

作者：

Amatya, Reeju ^{[1
,2
]}

Hwang, Seungmi ^{[3
,4
]}

Park, Taehoon ^{[1
,2
]}

Chung, Yoon Ju ^{[1
,2
]}

Ryu, Sehee ^{[1
,2
]}

Lee, Jihyeong ^{[3
,4
]}

Cheong, Heesun ^{[5
]}

Moon, Cheol ^{[6
]}

Min, Kyoung Ah ^{[3
,4
]}

Shin, Meong Cheol ^{[1
,2
]}

机构：

[1] Gyeongsang Natl Univ, Coll Pharm, 501 Jinju Daero, Jinju 52828, Gyeongnam, South Korea

[2] Gyeongsang Natl Univ, Res Inst Pharmaceut Sci, 501 Jinju Daero, Jinju 52828, Gyeongnam, South Korea

[3] Inje Univ, Coll Pharm, 197 Injero, Gimhae 50834, Gyeongnam, South Korea

[4] Inje Univ, Inje Inst Pharmaceut Sci & Res, 197 Injero, Gimhae 50834, Gyeongnam, South Korea

[5] Natl Canc Ctr, Div Canc Biol, 323 Ilsan Ro, Goyang 10408, Gyeonggi Do, South Korea

[6] Sunchon Natl Univ, Coll Pharm, 255 Jungang Ro, Sunchon 57922, Jeonnam, South Korea

来源：

PHARMACEUTICAL RESEARCH | 2021年 / 38卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

cancer; bovine serum albumin; hydrogel; photothermal therapy; silver nanoparticle; SILVER NANOPARTICLES; HYPERTHERMIA; TOXICITY; THERAPY;

D O I：

10.1007/s11095-021-03038-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Purpose To develop a hydrogel film containing bovine serum albumin (BSA)-coated silver nanoparticles (BSA/AgNP) and evaluate its applicability for topical photothermal treatment (PTT) of skin cancer. Methods BSA/AgNP-loaded hydrogel films were prepared and their swelling, bioadhesive, mechanical, and photothermal properties were characterized in vitro and in vivo. Results The synthesized BSA/AgNP exhibited a narrow size distribution with good size stability and, notably, possessed great photothermal activity that could stably maintain through repetitive laser irradiation. The BSA/AgNP-loaded hydrogel films showed favorable swelling, bioadhesive, tensile, and photothermal properties. Based on these results, when tested the anti-cancer effects in B16F10 s.c. tumor-bearing mice, the PTT with the topical treatment of BSA/AgNP-loaded hydrogel films could significantly inhibit the tumor growth by a single treatment with no apparent toxicity. Conclusions Overall, the results of this study demonstrated that the BSA/AgNP-loaded hydrogel films may serve as an effective but safe topical PTT agent for the treatment of skin cancer.

引用

页码：873 / 883

页数：11

共 41 条

[1]

Ahmad S A., 2020, Materials Science for Energy Technologies, V3, P756, DOI [10.1016/j.mset.2020.09.002, DOI 10.1016/J.MSET.2020.09.002]

[2] Hydrogel: Preparation, characterization, and applications: A review [J].