Organocatalytic Asymmetric Aza-Michael Additions

被引:474
作者
Enders, Dieter [1 ]
Wang, Chuan [1 ]
Liebich, Jens X. [1 ]
机构
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
关键词
asymmetric synthesis; Bronsted catalysis; domino reactions; Michael addition; organocatalysis; ENANTIOSELECTIVE CONJUGATE ADDITION; BETA-AMINO ACIDS; STEREOSELECTIVE-SYNTHESIS; N-HETEROCYCLES; O-BENZYLHYDROXYLAMINE; AROMATIC-AMINES; TMS-SAMP; ALPHA; BETA-UNSATURATED ALDEHYDES; CHIRAL EQUIVALENT; ALPHA-ALKYLATION;
D O I
10.1002/chem.200902236
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The catalytic aza-Michael addition is an important reaction within synthetic organic chemistry, given the significance of the biologically and synthetically interesting products, such as beta-amino acids and beta-lactams. In the last decade organocatalysis emerged as a powerful tool in asymmetric synthesis and had a large impact on the development of asymmetric and catalytic conjugate additions of nitrogen nucleophiles to Michael acceptors. In this review a first summary of the recent rapid progress of asymmetric organocatalyzed aza-Michael reactions is presented.
引用
收藏
页码:11058 / 11076
页数:19
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