microRNAs in Inflammation

被引：190

作者：

Sonkoly, Eniko ^{[1
]}

Pivarcsi, Andor ^{[1
]}

机构：

[1] Karolinska Univ Hosp, Mol Dermatol Res Grp, Unit Dermatol & Venerol,Karolinska Inst, Ctr Mol Med L8 02,Dept Med, Stockholm, Sweden

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2009年 / 28卷 / 06期

关键词：

microRNA; inflammation; inflammatory diseases; immunity; T-CELL; DOWN-REGULATION; MIRNA EXPRESSION; GENE-EXPRESSION; RAPID CHANGES; TARGET GENES; RNA; DIFFERENTIATION; REGULATORS; MIR-155;

D O I：

10.3109/08830180903208303

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

microRNAs are small noncoding RNAs that regulate protein-coding genes via post-transcriptional repression. Most protein-coding genes are subjected to microRNA-mediated regulation, making the potential effect of these small molecules on regulatory networks enormous. Recent research has implicated miRNAs in the regulation of innate and adaptive immune responses as well as inflammatory networks in various cell and tissue types. In this review, we summarize the current knowledge about miRNAs in immunity and inflammation, focusing on the recent results on miRNAs involved in the regulation of immune responses and inflammatory diseases.

引用

页码：535 / 561

页数：27

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