Leukocyte profile of cattle persistently infected with bovine viral diarrhea virus

被引：16

作者：

Brewoo, Joseph N. ^{[1
]}

Haase, Christopher J. ^{[1
]}

Sharp, Patricia ^{[1
]}

Schultz, Ronald D. ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2007年 / 115卷 / 3-4期

关键词：

BVDV; persistent infection; phagocytosis; leukocyte profile;

D O I：

10.1016/j.vetimm.2006.10.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Animals acutely infected with bovine viral diarrhea virus (BVDV) exhibit transient immunosuppression as a result of the virus' predilection for cells that play critical roles in the host immune system. Acute BVDV infections have major effects on thymic and follicular T-lymphocytes, as well as follicular B-lymphocytes, often resulting in severe reduction in circulating numbers of lymphocytes and suppression of functional activities of these cells. Granulocytes and monocytes are equally susceptible to BVDV infections with reduction in numbers and suppression functions. However, there is limited information on the leukocyte profile of cattle persistently infected (PI) with BVDV. This study reports on phagocytic activities of granulocytes and monocytes as well as immunophenotyping by flow cytometric analysis of leukocytes isolated from healthy non-PI (NPI) and PI animals. No significant differences were found between the leukocyte profiles and the phagocytic activities of PI animals when compared to a group of healthy NPI animals. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：369 / 374

页数：6

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