Adult brain aging investigated using BMC-mcDESPOT-based myelin water fraction imaging

被引：49

作者：

Bouhrara, Mustapha ^{[1
]}

Rejimon, Abinand C. ^{[1
]}

Cortina, Luis E. ^{[1
]}

Khattar, Nikkita ^{[1
]}

Bergeron, Christopher M. ^{[1
]}

Ferrucci, Luigi ^{[2
]}

Resnick, Susan M. ^{[3
]}

Spencer, Richard G. ^{[1
]}

机构：

[1] NIA, Lab Clin Invest, NIH, Baltimore, MD 21224 USA

[2] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA

[3] NIA, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA

来源：

NEUROBIOLOGY OF AGING | 2020年 / 85卷

基金：

美国国家卫生研究院;

关键词：

Myelin water fraction; Normal aging; Quantitative MRI; BMC-mcDESPOT; WHITE-MATTER CHANGES; MULTIPLE-SCLEROSIS; IN-VIVO; ALZHEIMERS-DISEASE; RELAXATION-TIME; AGE; POSTMORTEM; MRI; PROLIFERATION; INTEGRITY;

D O I：

10.1016/j.neurobiolaging.2019.10.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The relationship between regional brain myelination and aging has been the subject of intense study, with magnetic resonance imaging perhaps the most effective modality for elucidating this. However, most of these studies have used nonspecific methods to probe myelin content, including diffusion tensor imaging, magnetization transfer ratio, and relaxation times. In the present study, we used the BMC-mcDESPOT analysis, a direct and specific method for imaging of myelin water fraction (MWF), a surrogate of myelin content. We investigated age-related differences in MWF in several brain regions in a large cohort of cognitively unimpaired participants, spanning a wide age range. Our results indicate a quadratic, inverted U-shape, relationship between MWF and age in all brain regions investigated, suggesting that myelination continues until middle age followed by decreases at older ages. We also observed that these age-related differences vary across different brain regions, as expected. Our results provide evidence for nonlinear associations between age and myelin in a large sample of well-characterized adults, using a direct myelin content imaging method. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：131 / 139

页数：9

共 63 条

[1] Diffusion tensor imaging of the brain [J].

Alexander, Andrew L. ;

Lee, Jee Eun ;

Lazar, Mariana ;

Field, Aaron S. .

NEUROTHERAPEUTICS, 2007, 4 (03) :316-329

[2] MRI-Based Myelin Water Imaging: A Technical Review [J].

Alonso-Ortiz, Eva ;

Levesque, Ives R. ;

Pike, G. Bruce .

MAGNETIC RESONANCE IN MEDICINE, 2015, 73 (01) :70-81

[3] Adult age differences in subcortical myelin content are consistent with protracted myelination and unrelated to diffusion tensor imaging indices [J].

Arshad, Muzamil ;

Stanley, Jeffrey A. ;

Raz, Naftali .

NEUROIMAGE, 2016, 143 :26-39

[4] White matter structural integrity in healthy aging adults and patients with Alzheimer disease - A magnetic resonance imaging study [J].

Bartzokis, G ;

Cummings, JL ;

Sultzer, D ;

Henderson, VW ;

Nuechterlein, KH ;

Mintz, J .

ARCHIVES OF NEUROLOGY, 2003, 60 (03) :393-398

[5] Lifespan trajectory of myelin integrity and maximum motor speed [J].

Bartzokis, George ;

Lu, Po H. ;

Tingus, Kathleen ;

Mendez, Mario F. ;

Richard, Aurore ;

Peters, Douglas G. ;

Oluwadara, Bolanle ;

Barrall, Katherine A. ;

Finn, J. Paul ;

Villablanca, Pablo ;

Thompson, Paul M. ;

Mintz, Jim .

NEUROBIOLOGY OF AGING, 2010, 31 (09) :1554-1562

[6] Differential aging of cerebral white matter in middle-aged and older adults: A seven-year follow-up [J].

Bender, Andrew R. ;

Voelkle, Manuel C. ;

Raz, Naftali .

NEUROIMAGE, 2016, 125 :74-83

[7] Discovering the false discovery rate [J].

Benjamini, Yoav .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 2010, 72 :405-416

[8] The influence of brain iron on myelin water imaging [J].

Birkl, Christoph ;

Birkl-Toeglhofer, Anna Maria ;

Endmayr, Verena ;

Hoeftberger, Romana ;

Kasprian, Gregor ;

Krebs, Claudia ;

Haybaeck, Johannes ;

Rauscher, Alexander .

NEUROIMAGE, 2019, 199 :545-552

[9] Evaluation of white matter myelin water fraction in chronic stroke [J].

Borich, M. R. ;

MacKay, A. L. ;

Vavasour, I. M. ;

Rauscher, A. ;

Boyd, L. A. .

NEUROIMAGE-CLINICAL, 2013, 2 :569-580

[10]

Bouhrara M, 2015, MAGNETIC RESONANCE M, V75, P2406, DOI [10.1002/mrm.25801, DOI 10.1002/MRM.25801.]

← 1 2 3 4 5 6 7 →