Cancer stem cell markers ALDH1 and Bmi1 expression in oral erythroplakia revisited: Implication for driving the process of field cancerization

被引：12
作者：
Feng, Jinqiu [1 ,2 ]
Zhou, Zengtong [3 ]
Shi, Linjun [3 ]
Yang, Xi [4 ,5 ]
Liu, Wei [4 ,5 ]
机构：
[1] Fudan Univ, Shanghai Stomatol Hosp, Dept Pediat Dent, Shanghai, Peoples R China
[2] Fudan Univ, Shanghai Stomatol Hosp, Oral Biomed Engn Lab, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oral Mucosal Dis, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai Key Lab Stomatol, Shanghai Peoples Hosp 9,Coll Stomatol,Sch Med, Shanghai, Peoples R China
[5] Shanghai Jiao Tong Univ, Shanghai Res Inst Stomatol, Natl Clin Res Ctr Oral Dis, Sch Med, Shanghai, Peoples R China
来源：
JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2020年 / 49卷 / 01期
关键词：
ALDH1; Bmi1; cancer stem cells; field cancerization; oral potentially malignant disorder;
D O I：
10.1111/jop.12955
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The correlation of ALDH1 and Bmi1 expression in potentially malignant oral erythroplakia (OE) with oral carcinoma development was reported in our earlier study. Interestingly, a model of field cancerization orchestrated by the cancer stem cells (CSC) was proposed and suggested the identification of CSC-specific markers is useful for prognosis and providing novel targets for prevention and treatment of field cancerization. We revisited the correlation of ALDH1 and Bmi1 expression in OE with the second and multiple carcinomas development. Strikingly, we observed that the expression of ALDH1 and Bmi1 within a single potentially malignant OE lesion significantly correlate with subsequently developing multiple and multifocal carcinomas, which parallels the process of oral field cancerization. Significantly, ALDH1 and Bmi1 are well-defined markers of CSC for head and neck cancer. Consequently, we provided a preliminary evidence for CSC driving the process of field cancerization.
引用
收藏
页码：96 / 99
页数：4
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