Glucose-functionalized amino-OPEs as biocompatible photosensitizers in PDT

被引：28

作者：

Deni, Elisa ^{[1
]}

Zamarron, Alicia ^{[2
]}

Bonaccorsi, Paola ^{[1
]}

Carmen Carreno, M. ^{[3
]}

Juarranz, Angeles ^{[2
]}

Puntoriero, Fausto ^{[1
]}

Sciortino, Maria Teresa ^{[1
]}

Ribagorda, Maria ^{[3
]}

Barattucci, Anna ^{[1
]}

机构：

[1] Univ Messina, Dipartimento Sci Chim Biol Farmaceut & Ambientali, Messina, Italy

[2] Univ Autonoma Madrid, Dept Biol, Madrid, Spain

[3] Univ Autonoma Madrid, Dept Quim Organ, Madrid, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 111卷

关键词：

Phothodynamic therapy; Phothosensitizer; Oligo(phenylene ethynylene); Singlet oxygen production; Glucose base photosensitizers; PHOTODYNAMIC THERAPY; SINGLET OXYGEN; PHOTOTHERAPY; CANCER; DEATH; MECHANISMS; COMPLEXES; APOPTOSIS; SYSTEMS; CELLS;

D O I：

10.1016/j.ejmech.2016.01.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Photodynamic therapy (PDT) is a minimally invasive procedure that can provide a selective eradication of neoplastic diseases by the combined effect of a photosensitizer, light and oxygen. New amino oligo(phenylene-ethynylene)s (OPEs), bearing hydrophilic glucoside terminations, have been prepared, characterized and tested as photosensitizers in PDT. The effectiveness of these compounds in combination with UVA light has been checked on two tumor cell lines (HEp-2 and HeLa cells, derived from a larynx carcinoma and a cervical carcinoma, respectively). The compounds triggered a mitotic blockage that led to the cell death, being the effect active up to 3 mu m concentration. The photophysical properties of OPEs, such as high quantum yield, stability, singlet oxygen production, biocompatibility, easy cell internalization and very good response even at low concentration, make them promising photosensitizers in the application of PDT. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

页码：58 / 71

页数：14

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