Histopathological and genotoxic effects of chlorpyrifos in rats

被引：38

作者：

Ezzi, Lobna ^{[1
]}

Salah, Imen Belhadj ^{[1
]}

Haouas, Zohra ^{[1
]}

Sakly, Amina ^{[1
]}

Grissa, Intissar ^{[1
]}

Chakroun, Sana ^{[1
]}

Kerkeni, Emna ^{[1
]}

Hassine, Mohsen ^{[2
]}

Mehdi, Meriem ^{[1
]}

Ben Cheikh, Hassen ^{[1
]}

机构：

[1] Univ Monastir, Fac Med, Lab Histol & Cytogenet, Res Unit Genet Genotox & Childhood Illness UR12ES, St Avicenne, Monastir 5019, Tunisia

[2] Fattouma Bourguiba Univ Hosp Monastir, Hematol Lab, Monastir, Tunisia

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2016年 / 23卷 / 05期

关键词：

Chlorpyrifos; Genotoxicity; Hematological parameters; Liver; Organophosphate; MICRONUCLEUS TEST; DNA-DAMAGE; COMET ASSAY; PERIPHERAL-BLOOD; PIPIENS DIPTERA; PROTECTIVE ROLE; CULEX-PIPIENS; BONE-MARROW; VITAMIN-E; IN-VIVO;

D O I：

10.1007/s11356-015-5722-x

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study aims to investigate the effects of chlorpyrifos's sub-acute exposure on male rats. Two groups with six animals each were orally treated, respectively, with 3.1 mg/kg b w and 6.2 mg/kg b w of chlorpyrifos during 4 weeks. The genotoxic effect of chlopyrifos was investigated using the comet assay and the micronucleus test. Some hematological and liver's histopathological changes were also evaluated. Results revealed that chlorpyrifos induced histopathological alterations in liver parenchyma. The lymphoid infiltration observed in liver sections and the increase in white blood cells parameter are signs of inflammation. A significant increase in the platelet' count and in polychromatic erythrocytes/normochromatic erythrocytes (PCE/NCE) ratio was observed in chlorpyrifos-treated groups which could be due to the stimulatory effect of chlorpyrifos on cell formation in the bone marrow at lower doses. In addition, the increase of bone marrow micronucleus percentage and the comet tail length revealed a genotoxic potential of chlorpyrifos in vivo.

引用

页码：4859 / 4867

页数：9

共 49 条

[1] Ameliorative effect of vitamin C on chronic chlorpyrifos-induced erythrocyte osmotic fragility in Wistar rats [J].