Colocalization of 5-HT1F receptor and calcitonin gene-related peptide in rat vestibular nuclei

被引：40

作者：

Ahn, Seong-Ki ^{[1
,2
]}

Khalmuratova, Roza ^{[1
]}

Jeon, Sea-Yuong ^{[1
,2
]}

Kim, Jin-Pyeong ^{[1
,2
]}

Park, Jung Je ^{[1
,2
]}

Hur, Dong Gu ^{[1
]}

Balaban, Carey D. ^{[3
]}

机构：

[1] Gyeongsang Natl Univ, Coll Med, Dept Otolaryngol, Jinju 660702, South Korea

[2] Gyeongsang Natl Univ, Coll Med, Inst Hlth Sci, Jinju 660702, South Korea

[3] Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15260 USA

来源：

NEUROSCIENCE LETTERS | 2009年 / 465卷 / 02期

关键词：

Migraine; Vertigo; 5-HT1F; Calcitonin gene-related peptide; Vestibular nuclei; TRIGEMINAL GANGLION NEURONS; MIGRAINE; AGONISTS; CGRP; IMMUNOREACTIVITY; VERTIGO;

D O I：

10.1016/j.neulet.2009.09.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to determine whether calcitonin gene-related peptide (CGRP) colocalizes with 5-HT1F receptor in rat vestibular nuclei using a double immunohistochemical staining procedure The frequent co-occurrence of migraine and balance disorders suggests a pathophysiologic link between the two However. the mechanism of migrainous vertigo has not been elucidated, though serotonin (5-HT) and its receptors are believed to involve in the pathogenesis of migrainous vertigo. Furthermore 5-HT1F, receptor agonists and CGRP receptor antagonists have recently attracted attention as potential treatments for migraine, and CGRP release from trigeminal neurons has been associated with migraine This study demonstrates the colocalization of 5-HT1F receptor and CGRP in the rat vestibular nuclei, which suggests that 5-HT1F receptor regulates the release of CGRP from vestibular nuclei This finding indicates that 5-HT1F receptor agonists may ameliorate migrainous vertigo by attenuating elevated levels of CGRP release from vestibular nuclei. (c) 2009 Elsevier Ireland Ltd All rights reserved.

引用

页码：151 / 156

页数：6

共 21 条

[1]

Agosti Reto M., 2007, CNS & Neurological Disorders-Drug Targets, V6, P235

[2] Central sensitization theory of migraine: Clinical implications [J].

Dodick, David ;

Silberstein, Stephen .

HEADACHE, 2006, 46 :S182-S191

[3] Motion sickness and migraine: optokinetic stimulation increases scalp tenderness, pain sensitivity in the fingers and photophobia [J].

Drummond, PD .

CEPHALALGIA, 2002, 22 (02) :117-124

[4] Inhibition of calcitonin gene-related peptide function: A promising strategy for treating migraine [J].

Durham, Paul L. .

HEADACHE, 2008, 48 (08) :1269-1275

[5] Calcitonin gene-related peptide (CGRP) and migraine [J].

Durham, PL .

HEADACHE, 2006, 46 :S3-S8

[6] Migrainous vertigo: development of a pathogenetic model and structured diagnostic interview [J].

Furman, JM ;

Marcus, DA ;

Balaban, CD .

CURRENT OPINION IN NEUROLOGY, 2003, 16 (01) :5-13

[7] Drug therapy: Migraine - Current understanding and treatment. [J].

Goadsby, PJ ;

Lipton, RB ;

Ferrari, MD .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (04) :257-270

[8] Medical management of migraine-related dizziness and vertigo [J].

Johnson, GD .

LARYNGOSCOPE, 1998, 108 (01) :1-28

[9] 5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs [J].

Johnson, KW ;

Schaus, JM ;

Durkin, MM ;

Audia, JE ;

Kaldor, SW ;

Flaugh, ME ;

Adham, N ;

Zgombick, JM ;

Cohen, ML ;

Branchek, TA ;

Phebus, LA .

NEUROREPORT, 1997, 8 (9-10) :2237-2240

[10] Serotonin-induced plasma extravasation in the murine inner ear: possible mechanism of migraine-associated inner ear dysfunction [J].

Koo, J. -W ;

Balaban, C. D. .

CEPHALALGIA, 2006, 26 (11) :1310-1319

← 1 2 3 →