1,2,3-Triazole Fused Quinoline-Peptidomimetics: Studies on Synthesis, DNA Binding and Photonuclease Activity

被引：29

作者：

Aravinda, T. ^{[1
]}

Naik, H. S. Bhojya ^{[1
]}

Naik, H. R. Prakash ^{[1
]}

机构：

[1] Kuvempu Univ, Dept Studies & Res Ind Chem, Shankaraghatta 577451, Karnataka, India

来源：

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS | 2009年 / 15卷 / 04期

关键词：

1,2,3-triazole-quinoline; Peptidomimetics; DNA binding-photocleavage; CRYSTAL-STRUCTURE; TERMINAL ALKYNES; INHIBITORS; FOLDAMERS; CLEAVAGE; AZIDES; DERIVATIVES; COMPLEXES;

D O I：

10.1007/s10989-009-9188-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present, simple approach for the accession of 1,2,3-triazole fused quinoline peptide analogues from 3-(azidomethyl)-2-chloroquinoline in a three-step mechanistic pathway. The UV-Visible absorbance plot shows dynamic interaction of parent triazole derivative with CT DNA as efficient DNA intercalator (K (b) = 4.6 x 10(-4) M-1). Finally, the efficient DNA damage was observed on photo-irradiation at 360 nm in the presence of 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionic acid 1-(2-chloro-quinolin-3-ylmethyl)-1H-[1,2,3]triazole-4-ylmethyl ester (6a).

引用

页码：273 / 279

页数：7

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