Enhanced Protection Against Diarrhea Among Breastfed Infants of Nonsecretor Mothers

被引：5
作者：
Muthumuni, Dhasni [1 ,2 ]
Miliku, Kozeta [1 ,2 ]
Wade, Kaitlin H. [3 ,4 ]
Timpson, Nicholas J. [3 ,4 ,5 ]
Azad, Meghan B. [1 ,2 ]
机构：
[1] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada
[2] Childrens Hosp Res Inst Manitoba, Manitoba Interdisciplinary Lactat Ctr MILC, Winnipeg, MB, Canada
[3] Univ Bristol, Fac Hlth Sci, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England
[4] Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England
[5] Univ Bristol, Avon Longitudinal Study Parents & Children, Bristol, Avon, England
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2021年 / 40卷 / 03期
基金：
英国惠康基金;
关键词：
fucosyltransferase-2; secretor status; breast milk; diarrhea; pediatrics;
D O I：
10.1097/INF.0000000000003014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Diarrhea is a major cause of infant mortality. Being a "nonsecretor" (having an inactive fucosyltransferase-2 gene) protects against diarrhea by inhibiting enteric infections. Breastfeeding also protects against diarrhea; however, the impact of maternal secretor status is unknown. In the ALSPAC cohort (N = 4971), we found that breastfeeding by nonsecretor mothers was especially protective against diarrhea, which could inform new prevention strategies.
引用
收藏
页码：260 / 263
页数：4
相关论文
共 47 条
  • [31] Selenium status in lactating mothers-infants and its potential protective role against the neurotoxicity of methylmercury, lead, manganese, and DDT
    Al-Saleh, Iman
    Al-Mohawes, Somiah
    Al-Rouqi, Reem
    Elkhatib, Rola
    ENVIRONMENTAL RESEARCH, 2019, 176
  • [32] Exopolysaccharide from Lactobacillus plantarum LRCC5310 offers protection against rotavirus-induced diarrhea and regulates inflammatory response
    Kim, Kiyoung
    Lee, Gyeonghweon
    Hien Dang Thanh
    Kim, Jong-Hwa
    Konkit, Maytiya
    Yoon, Seokmin
    Park, Miri
    Yang, Siyoung
    Park, Eunsup
    Kim, Wonyong
    JOURNAL OF DAIRY SCIENCE, 2018, 101 (07) : 5702 - 5712
  • [33] Exposure and risk assessment of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) for primiparous mothers and breastfed infants in Penang, Malaysia
    Leong, Yin-Hui
    Azmi, Nurul Izzati
    Majid, Mohamed Isa Abdul
    Wen, Sheng
    FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2021, 38 (08): : 1416 - 1426
  • [34] Breast milk vitamin B12 concentration and incidence of diarrhea and respiratory infections among infants in urban Tanzania: a prospective cohort study
    Lweno, Omar N.
    Sudfeld, Christopher R.
    Hertzmark, Ellen
    Manji, Karim P.
    Darling, Anne Marie
    Fawzi, Wafaie W.
    BMC RESEARCH NOTES, 2020, 13 (01)
  • [35] Breast milk vitamin B12 concentration and incidence of diarrhea and respiratory infections among infants in urban Tanzania: a prospective cohort study
    Omar N. Lweno
    Christopher R. Sudfeld
    Ellen Hertzmark
    Karim P. Manji
    Anne Marie Darling
    Wafaie W. Fawzi
    BMC Research Notes, 13
  • [36] Zinc during and in convalescence from diarrhea has no demonstrable effect on subsequent morbidity and anthropometric status among infants <6 mo of age
    Walker, Christa L. Fischer
    Bhutta, Zulfiqar A.
    Bhandari, Nita
    Teka, Telahun
    Shahid, Farhana
    Taneja, Sunita
    Black, Robert E.
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 85 (03) : 887 - 894
  • [37] Human rotavirus vaccine Rotarix™ provides protection against diverse circulating rotavirus strains in African infants: a randomized controlled trial
    Steele, Andrew Duncan
    Neuzil, Kathleen M.
    Cunliffe, Nigel A.
    Madhi, Shabir A.
    Bos, Pieter
    Ngwira, Bagrey
    Witte, Desiree
    Todd, Stacy
    Louw, Cheryl
    Kirsten, Mari
    Aspinall, Sanet
    Van Doorn, Leen Jan
    Bouckenooghe, Alain
    Suryakiran, Pemmaraju V.
    Han, Htay Htay
    BMC INFECTIOUS DISEASES, 2012, 12
  • [38] Medical treatment-seeking behaviour for childhood diarrhea among Haitian mothers: secondary data analysis from the 2016–2017 Haitian demographic and health survey
    David Jean Simon
    Vénunyé Claude Kondo Tokpovi
    Adama Ouedraogo
    Ann Kiragu
    BMC Pediatrics, 25 (1)
  • [39] Prevalence and Determinants of Appropriate Child Feeding Practice Among Mothers Having Children with and without Diarrhea Aged 6-23 Months in Debre Berhan Town, Ethiopia
    Asfaw, Tsegahun
    RESEARCH AND REPORTS IN NEONATOLOGY, 2021, 11 : 35 - 42
  • [40] Norovirus diarrhea is significantly associated with higher counts of fecal histo-blood group antigen expressing Enterobacter cloacae among black South African infants
    Magwira, Cliff A.
    Steele, Duncan
    Seheri, M. L.
    GUT MICROBES, 2021, 13 (01)
12345