Preparation of biodegradable PLA/PLGA membranes with PGA mesh and their application for periodontal guided tissue regeneration

被引：17

作者：

Kim, Eun Jin ^{[1
]}

Yoon, Suk Joon ^{[2
]}

Yeo, Guw-Dong ^{[3
]}

Pai, Chaul-Min ^{[3
]}

Kang, Inn-Kyu ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Dept Polymer Sci, Taegu 702701, South Korea

[2] Sookmyung Womens Univ, Dept Biol, Seoul 140742, South Korea

[3] Samyang Cent R&D Ctr, Taejon 305717, South Korea

来源：

BIOMEDICAL MATERIALS | 2009年 / 4卷 / 05期

关键词：

POLYLACTIC ACID; ATTACHMENT FORMATION; BONE REGENERATION; BIOCOMPATIBILITY; COPOLYMERS; COLLAGEN; THERAPY; HUMANS;

D O I：

10.1088/1748-6041/4/5/055001

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A biodegradable polylactic acid (PLA)/poly(glycolide-co-lactide) copolymer (PLGA) membrane with polyglycolic acid (PGA) mesh was prepared to aid the effective regeneration of defective periodontal tissues. The microporous membrane used in this study consists of biodegradable polymers, and seems to have a structure to provide appropriate properties for periodontal tissue regeneration. Based on the albumin permeation test, it is known that the biodegradable membrane exhibits the suitable permeability of nutrients. The membrane maintained its physical integrity for 6-8 weeks, which could be sufficient to retain space in the periodontal pocket. Cell attachment and cytotoxicity tests were performed with respect to the evaluation of biocompatibility of the membrane. As a result, the membrane did not show any cytotoxicity. The safety and therapeutic efficacies of the biodegradable membranes were confirmed in animal tests.

引用

页数：7

共 26 条

[1] Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid polyglycolic acid copolymers [J].