Increasing Incidence of Intrahepatic Cholangiocarcinoma and its Relationship to Chronic Viral Hepatitis

被引：48

作者：

Chang, Kwang-Yu ^{[2
,3
]}

Chang, Jang-Yang ^{[2
,3
]}

Yen, Yun ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Div Clin & Mol Pharmacol, Duarte, CA 91010 USA

[2] Natl Hlth Res Inst, Natl Inst Canc Res, Miaoli, Taiwan

[3] Natl Cheng Kung Univ, Dept Internal Med, Natl Cheng Kung Univ Hosp, Coll Med, Tainan 70101, Taiwan

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2009年 / 7卷 / 04期

关键词：

Intrahepatic cholangiocarcinoma; hepatitis C virus; hepatitis B virus; incidence; risk factor; PRIMARY SCLEROSING CHOLANGITIS; C-VIRUS-INFECTION; BILIARY-TRACT CANCERS; UNITED-STATES; LIVER-CANCER; B-VIRUS; RISING INCIDENCE; MORTALITY-RATES; RISK-FACTORS; EPIDEMIOLOGY;

D O I：

10.6004/jnccn.2009.0030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary liver cancer is the sixth most common cancer and third most common cause of cancer death worldwide. Cholangiocarcinoma is the second most common primary liver tumor after hepatocellular carcinoma. Because the incidence of intrahepatic cholangiocarcinoma is rising in most areas worldwide, identification of the main causes' of this problem is urgently needed. Despite well-known risk factors in the development of intrahepatic cholangiocarcinoma, recent reports focus on chronic hepatitis B and C viral infections because an increasing number of studies have observed an association. The relationship, however, is still not conclusive because of the diversity in clinical reports and the lack of in vitro evidences. This issue should be emphasized and further investigation is required for clarification. (JNCCN 2009;7:423-427)

引用

页码：423 / 427

页数：5