Synthesis of fluorinated heterocycles

被引：171

作者：

Sloop, JC

Bumgardner, CL

Loehle, WD

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

[2] US Mil Acad, Dept Chem, W Point, NY 10996 USA

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2002年 / 118卷 / 1-2期

关键词：

fluorination; pyrazole; isoxazole; pyrimidine; quinoline;

D O I：

10.1016/S0022-1139(02)00221-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Selected 1,3-diketones having a trifluoromethyl group and/or a fluorine in the 2-position were condensed with aromatic hydrazines, hydroxylamine, urea, thiourea, guanidine, and substituted anilines producing pyrazoles, isoxazoles, pyrimidines, and quinolines, respectively, in yields ranging from 27 to 87%. (C) 2002 Elsevier Science B.V. All rights reserved.

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页码：135 / 147

页数：13

相关论文

共 26 条

[1] RING-FLUORINATED PYRAZOLES [J].

BUMGARDNER, CL ;

SLOOP, JC .

JOURNAL OF FLUORINE CHEMISTRY, 1992, 56 (02) :141-146

[2] FLUORESCENT EUROPIUM CHELATES DERIVED FROM FLUORINATED BETA-DIKETONES [J].

CHARLES, RG ;

RIEDEL, EP .

JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1967, 29 (03) :715-&

[3]

COMBES C, 1896, CHEM BER, V29, P2456

[4] SPECTROSCOPIC PROPERTIES AND GAS-CHROMATOGRAPHIC BEHAVIOR OF ARYL BETA-DIKETONES AND SELECTED CHELATES [J].

DILLI, S ;

ROBARDS, K .

JOURNAL OF CHROMATOGRAPHY, 1984, 312 (NOV) :109-120

[5]

DONLEAVY JJ, 1941, ORG SYNTH, V1, P422

[6]

Filler R., 1982, Biomedicinal Aspects of Fluorine Chemistry

[7] In vitro interactions of artemisinin with atovaquone, quinine, and mefloquine against Plasmodium falciparum. [J].

Gupta, S ;

Thapar, MM ;

Wernsdorfer, WH ;

Björkman, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (05) :1510-1515

[8]

HO R, 1968, AUST J CHEM, V312, P109

[9] THIO DERIVATIVES OF BETA-DIKETONES AND THEIR METAL CHELATES .9. NICKEL AND COPPER COMPLEXES OF SOME NEW FLUORINATED MONOTHIO-BETA-DIKETONES [J].

HO, RKY ;

LIVINGST.SE .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1968, 21 (07) :1781-&

[10]

Katsuyama I, 1997, SYNTHESIS-STUTTGART, P1321