Genetic approaches for the study of PTSD: Advances and challenges

被引：40

作者：

Banerjee, Sunayana B. ^{[1
]}

Morrison, Filomene G. ^{[1
,2
]}

Ressler, Kerry J. ^{[1
,2
]}

机构：

[1] Emory Univ, Behav Neurosci & Psychiat Disorders, Atlanta, GA 30329 USA

[2] McLean Hosp, 115 Mill St, Belmont, MA 02478 USA

来源：

NEUROSCIENCE LETTERS | 2017年 / 649卷

关键词：

POSTTRAUMATIC-STRESS-DISORDER; GENOME-WIDE ASSOCIATION; FACTOR VAL66MET POLYMORPHISM; GLUCOCORTICOID-RECEPTOR; SEROTONIN TRANSPORTER; FKBP5; POLYMORPHISMS; CHILDHOOD ABUSE; NO ASSOCIATION; DOPAMINE TRANSPORTER; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.neulet.2017.02.058

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Post-traumatic stress disorder (PTSD) is a highly debilitating stress and anxiety-related disorder that occurs in response to specific trauma or abuse. Genetic risk factors may account for up to 30-40% of the heritability of PTSD. Understanding the gene pathways that are associated with PTSD, and how those genes interact with the fear and stress circuitry to mediate risk and resilience for PTSD will enable the development of targeted therapies to prevent the occurrence of or decrease the severity of this complex multi-gene disorder. This review will summarize recent research on genetic approaches to understanding PTSD risk and resilience in human populations, including candidate genes and their epigenetic modifications, genome-wide association studies and neural imaging genetics approaches. Despite challenges faced within this field of study such as inconsistent results and replications, genetic approaches still offer exciting opportunities for the identification and development of novel therapeutic targets and therapies in the future. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：139 / 146

页数：8

共 106 条

[31] The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Predicts Response to Exposure Therapy in Posttraumatic Stress Disorder [J].

Felmingham, Kim L. ;

Dobson-Stone, Carol ;

Schofield, Peter R. ;

Quirk, Gregory J. ;

Bryant, Richard A. .

BIOLOGICAL PSYCHIATRY, 2013, 73 (11) :1059-1063

[32] Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder [J].

Frielingsdorf, Helena ;

Bath, Kevin G. ;

Soliman, Fatima ;

DiFede, JoAnn ;

Casey, B. J. ;

Lee, Francis S. .

PSYCHIATRIC AND NEUROLOGIC ASPECTS OF WAR, 2010, 1208 :150-157

[33] Effect of the common functional FKBP5 variant (rs1360780) on the hypothalamic-pituitary-adrenal axis and peripheral blood gene expression [J].

Fujii, Takashi ;

Hori, Hiroaki ;

Ota, Miho ;

Hattori, Kotaro ;

Teraishi, Toshiya ;

Sasayama, Daimei ;

Yamamoto, Noriko ;

Higuchi, Teruhiko ;

Kunugi, Hiroshi .

PSYCHONEUROENDOCRINOLOGY, 2014, 42 :89-97

[34] Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species [J].

Gee, Dylan G. ;

Fetcho, Robert N. ;

Jing, Deqiang ;

Li, Anfei ;

Glatt, Charles E. ;

Drysdale, Andrew T. ;

Cohen, Alexandra O. ;

Dellarco, Danielle V. ;

Yang, Rui R. ;

Dale, Anders M. ;

Jernigan, Terry L. ;

Lee, Francis S. ;

Casey, B. J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (16) :4500-4505

[35] Serotonin Transporter Gene (SLC6A4) Promoter Polymorphisms and the Susceptibility to Posttraumatic Stress Disorder in the General Population [J].

Grabe, Hans Joergen ;

Spitzer, Carsten ;

Schwahn, Christian ;

Marcinek, Agnes ;

Frahnow, Antje ;

Barnow, Sven ;

Lucht, Michael ;

Freyberger, Harald Juergen ;

John, Ulrich ;

Wallaschofski, Henri ;

Voelzke, Henry ;

Rosskopf, Dieter .

AMERICAN JOURNAL OF PSYCHIATRY, 2009, 166 (08) :926-933

[36] The 5-HTTLPR Polymorphism and Posttraumatic Stress Disorder: A Meta-Analysis [J].

Gressier, Florence ;

Calati, Raffaella ;

Balestri, Martina ;

Marsano, Agnese ;

Alberti, Siegfried ;

Antypa, Niki ;

Serretti, Alessandro .

JOURNAL OF TRAUMATIC STRESS, 2013, 26 (06) :645-653

[37] Altered gene expression of the innate immune, neuroendocrine, and nuclear factor-kappa B (NF-κB) systems is associated with posttraumatic stress disorder in military personnel [J].

Guardado, Pedro ;

Olivera, Anlys ;

Rusch, Heather L. ;

Roy, Michael ;

Martin, Christiana ;

Lejbman, Natasha ;

Lee, Hwyunhwa ;

Gill, Jessica M. .

JOURNAL OF ANXIETY DISORDERS, 2016, 38 :9-20

[38] No association between RORA polymorphisms and PTSD in two independent samples [J].

Guffanti, G. ;

Ashley-Koch, A. E. ;

Roberts, A. L. ;

Garrett, M. E. ;

Solovieff, N. ;

Ratanatharathorn, A. ;

De Vivo, I. ;

Dennis, M. ;

Ranu, H. ;

Smoller, J. W. ;

Liu, Y. ;

Purcell, S. M. ;

Beckham, J. ;

Hauser, M. A. ;

Koenen, K. C. .

MOLECULAR PSYCHIATRY, 2014, 19 (10) :1056-1057

[39] Plasma dopamine beta-hydroxylase activity in psychotic and non-psychotic post-traumatic stress disorder [J].

Hamner, MB ;

Gold, PB .

PSYCHIATRY RESEARCH, 1998, 77 (03) :175-181

[40] Relationship of a common polymorphism of the glucocorticoid receptor gene to traumatic memories and posttraumatic stress disorder in patients after intensive care therapy [J].

Hauer, Daniela ;

Weis, Florian ;

Papassotiropoulos, Andreas ;

Schmoeckel, Michael ;

Beiras-Fernandez, Andres ;

Lieke, Julia ;

Kaufmann, Ines ;

Kirchhoff, Fabian ;

Vogeser, Michael ;

Roozendaal, Benno ;

Briegel, Josef ;

de Quervain, Dominique ;

Schelling, Gustav .

CRITICAL CARE MEDICINE, 2011, 39 (04) :643-650

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