Tubakialactones A-E, new polyketides from the endophytic fungus Tubakia sp ECN-111

被引：5

作者：

Nakashima, Ken-ichi ^{[1
]}

Tomida, Junko ^{[2
]}

Hirai, Takao ^{[1
]}

Morita, Yuji ^{[2
]}

Kawamura, Yoshiaki ^{[2
]}

Inoue, Makoto ^{[1
]}

机构：

[1] Aichi Gakuin Univ, Lab Med Resources, Sch Pharm, Chikusa Ku, 1-100 Kusumoto Cho, Nagoya, Aichi 4648650, Japan

[2] Aichi Gakuin Univ, Microbiol Lab, Sch Pharm, Chikusa Ku, 1-100 Kusumoto Cho, Nagoya, Aichi 4648650, Japan

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 23期

关键词：

Endophytic fungi; Isocoumarins; Phthalides; Polyketides; Natural Products;

D O I：

10.1016/j.tetlet.2017.04.076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new isocoumarins and two new phthalides, tubakialactones A-E (1-5), together with three known polyketides including (R)-3,4-dihydro-4-hydroxyl-6,8-dimethoxy-4-methyl-3-methylene-1H-2-benzopyran-1-one (6), (-)-5,7-dimethoxy-3-methyl-1(3H)-isobenzofuranone (7), and isosclerone (8) were found in the endophytic fungus Tubakia sp. ECN-111 isolated from the leaves of Houttuynia cordata. The chemical structures of the new compounds were determined by spectroscopic analyses, including extensive 2D-NMR experiments. The absolute configuration of 3 and 7 was determined by optical rotation and circular dichroism. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2248 / 2251

页数：4

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