Long non-coding RNAs in antiviral immunity

被引：29

作者：

Vierbuchen, Tim ^{[1
]}

Fitzgerald, Katherine A. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Program Innate Immun, Worcester, MA 01655 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2021年 / 111卷

关键词：

lncRNA; Virus; Immunology; Infection; Cytokines; Interferon; CELL-DIFFERENTIATION; INTERFERON-GAMMA; MESSENGER-RNAS; GENE; EXPRESSION; MACROPHAGES; ACTIVATION; TRANSCRIPTION; MICROPEPTIDE; LANDSCAPE;

D O I：

10.1016/j.semcdb.2020.06.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tight regulation of the immune response is fundamental for efficient pathogen clearance and to prevent excessive inflammation. Long non-coding RNAs (lncRNAs) have emerged as potent regulators of the innate and adaptive immune responses to viral pathogens. Host-derived lncRNAs control the differentiation and polarization of immune cell populations and the production of cytokines, interferons and antiviral factors. This review provides an updated overview of lncRNAs that modulate viral replication or pathogenesis. Beyond that, viruses have developed lncRNA-based strategies to mask themselves from immune detection and evade antiviral immunity. A deeper understanding of lncRNA biology in the context of host-pathogen interactions may unveil new treatment strategies in the near future.

引用

页码：126 / 134

页数：9

共 145 条

[11] The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization [J].

Beeharry, Yasnee ;

Goodrum, Gabrielle ;

Imperiale, Christian J. ;

Pelchat, Martin .

SCIENTIFIC REPORTS, 2018, 8

[12] A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome [J].

Bhatta, Ankit ;

Atianand, Maninjay ;

Jiang, Zhaozhao ;

Crabtree, Juliet ;

Blin, Juliana ;

Fitzgerald, Katherine A. .

JOURNAL OF IMMUNOLOGY, 2020, 204 (02) :428-437

[13] G3BP1, G3BP2 and CAPRIN1 Are Required for Translation of Interferon Stimulated mRNAs and Are Targeted by a Dengue Virus Non-coding RNA [J].

Bidet, Katell ;

Dadlani, Dhivya ;

Garcia-Blanco, Mariano A. .

PLOS PATHOGENS, 2014, 10 (07)

[14] Determining exon connectivity in complex mRNAs by nanopore sequencing [J].

Bolisetty, Mohan T. ;

Rajadinakaran, Gopinath ;

Graveley, Brenton R. .

GENOME BIOLOGY, 2015, 16

[15]

Bonetti Alessandro, 2017, Current Opinion in Systems Biology, V3, P119, DOI 10.1016/j.coisb.2017.04.016

[16] A Viral Nuclear Noncoding RNA Binds Re-localized Poly(A) Binding Protein and Is Required for Late KSHV Gene Expression [J].

Borah, Sumit ;

Darricarrere, Nicole ;

Darnell, Alicia ;

Myoung, Jinjong ;

Steitz, Joan A. .

PLOS PATHOGENS, 2011, 7 (10)

[17] The Structural Biology of Toll-like Receptors [J].

Botos, Istvan ;

Segal, David M. ;

Davies, David R. .

STRUCTURE, 2011, 19 (04) :447-459

[18] Inflammasomes: mechanism of assembly, regulation and signalling [J].

Broz, Petr ;

Dixit, Vishva M. .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (07) :407-420

[19] Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls [J].

Cao, Huifen ;

Wahlestedt, Claes ;

Kapranov, Philipp .

TRENDS IN GENETICS, 2018, 34 (09) :704-721

[20] Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication [J].

Carnero, Elena ;

Barriocanal, Marina ;

Prior, Celia ;

Pablo Unfried, Juan ;

Segura, Victor ;

Guruceaga, Elizabeth ;

Enguita, Monica ;

Smerdou, Cristian ;

Gastaminza, Pablo ;

Fortes, Puri .

EMBO REPORTS, 2016, 17 (07) :1013-1028

← 1 2 3 4 5 6 7 8 9 10 →