Long non-coding RNAs in antiviral immunity

被引：29

作者：

Vierbuchen, Tim ^{[1
]}

Fitzgerald, Katherine A. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Program Innate Immun, Worcester, MA 01655 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2021年 / 111卷

关键词：

lncRNA; Virus; Immunology; Infection; Cytokines; Interferon; CELL-DIFFERENTIATION; INTERFERON-GAMMA; MESSENGER-RNAS; GENE; EXPRESSION; MACROPHAGES; ACTIVATION; TRANSCRIPTION; MICROPEPTIDE; LANDSCAPE;

D O I：

10.1016/j.semcdb.2020.06.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tight regulation of the immune response is fundamental for efficient pathogen clearance and to prevent excessive inflammation. Long non-coding RNAs (lncRNAs) have emerged as potent regulators of the innate and adaptive immune responses to viral pathogens. Host-derived lncRNAs control the differentiation and polarization of immune cell populations and the production of cytokines, interferons and antiviral factors. This review provides an updated overview of lncRNAs that modulate viral replication or pathogenesis. Beyond that, viruses have developed lncRNA-based strategies to mask themselves from immune detection and evade antiviral immunity. A deeper understanding of lncRNA biology in the context of host-pathogen interactions may unveil new treatment strategies in the near future.

引用

页码：126 / 134

页数：9

共 145 条

[1] cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING [J].

Ablasser, Andrea ;

Goldeck, Marion ;

Cavlar, Taner ;

Deimling, Tobias ;

Witte, Gregor ;

Roehl, Ingo ;

Hopfner, Karl-Peter ;

Ludwig, Janos ;

Hornung, Veit .

NATURE, 2013, 498 (7454) :380-+

[2] RNA targeting with CRISPR-Cas13 [J].

Abudayyeh, Omar O. ;

Gootenberg, Jonathan S. ;

Essletzbichler, Patrick ;

Han, Shuo ;

Joung, Julia ;

Belanto, Joseph J. ;

Verdine, Vanessa ;

Cox, David B. T. ;

Kellner, Max J. ;

Regev, Aviv ;

Lander, Eric S. ;

Voytas, Daniel F. ;

Ting, Alice Y. ;

Zhang, Feng .

NATURE, 2017, 550 (7675) :280-+

[3] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[4] Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity [J].

Amodio, Nicola ;

Stamato, Maria Angelica ;

Juli, Giada ;

Morelli, Eugenio ;

Fulciniti, Mariateresa ;

Manzoni, Martina ;

Taiana, Elisa ;

Agnelli, Luca ;

Cantafio, Maria Eugenia Gallo ;

Romeo, Enrica ;

Raimondi, Lavinia ;

Caracciolo, Daniele ;

Zuccala, Valeria ;

Rossi, Marco ;

Neri, Antonino ;

Munshi, Nikhil C. ;

Tagliaferri, Pierosandro ;

Tassone, Pierfrancesco .

LEUKEMIA, 2018, 32 (09) :1948-1957

[5] A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance [J].

Anderson, Douglas M. ;

Anderson, Kelly M. ;

Chang, Chi-Lun ;

Makarewich, Catherine A. ;

Nelson, Benjamin R. ;

McAnally, John R. ;

Kasaragod, Prasad ;

Shelton, John M. ;

Liou, Jen ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

CELL, 2015, 160 (04) :595-606

[6] Lambda interferon (IFN-λ), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo [J].

Ank, N ;

West, H ;

Bartholdy, C ;

Eriksson, K ;

Thomsen, AR ;

Paludan, SR .

JOURNAL OF VIROLOGY, 2006, 80 (09) :4501-4509

[7] Immunobiology of Long Noncoding RNAs [J].

Atianand, Maninjay K. ;

Caffrey, Daniel R. ;

Fitzgerald, Katherine A. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 35, 2017, 35 :177-198

[8] A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation [J].

Atianand, Maninjay K. ;

Hu, Wenqian ;

Satpathy, Ansuman T. ;

Shen, Ying ;

Ricci, Emiliano P. ;

Alvarez-Dominguez, Juan R. ;

Bhatta, Ankit ;

Schattgen, Stefan A. ;

McGowan, Jason D. ;

Blin, Juliana ;

Braun, Joerg E. ;

Gandhi, Pallavi ;

Moore, Melissa J. ;

Chang, Howard Y. ;

Lodish, Harvey F. ;

Caffrey, Daniel R. ;

Fitzgerald, Katherine A. .

CELL, 2016, 165 (07) :1672-1685

[9] Long non-coding RNA BST2/BISPR is induced by IFN and regulates the expression of the antiviral factor tetherin [J].

Barriocanal, Marina ;

Camero, Elena ;

Segura, Victor ;

Fortes, Puri .

FRONTIERS IN IMMUNOLOGY, 2015, 5 :1-13

[10] Long noncoding RNAs and the regulation of innate immunity and host-virus interactions [J].

Basavappa, Megha ;

Cherry, Sara ;

Henao-Mejia, Jorge .

JOURNAL OF LEUKOCYTE BIOLOGY, 2019, 106 (01) :83-93

← 1 2 3 4 5 6 7 8 9 10 →