Crystal structure and superoxide dismutase activity of a six-coordinate manganese(III) complex

被引：31

作者：

Lin, J ^{[1
]}

Tu, C ^{[1
]}

Lin, H ^{[1
]}

Jiang, PJ ^{[1
]}

Ding, J ^{[1
]}

Guo, ZJ ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Coordinat Chem, Inst Coordinat Chem, Nanjing 210093, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2003年 / 6卷 / 03期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

crystal structure; manganese(III) complex; superoxide dismutase mimic; six-coordinate complex;

D O I：

10.1016/S1387-7003(02)00741-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A six-coordinate manganese(III) complex [Mn(bpb)(H2O)Cl], where H(2)bpb is N,N-(1,2-phenylene)bis(pyridine-2-carboxaminde), was prepared and characterized by X-ray crystallography. It crystallizes in the monoclinic system, space group P 2(1)/c with a = 6.735(l) Angstrom, b = 22.910(4) Angstrom, c = 11.647(2) Angstrom, beta = 102.20(l)degrees, Z = 4 and V = 1756.5(5) Angstrom(3). Mn (III) in the complex adopts an octahedral coordination geometry. The cyclic voltammetry of the complex recorded in DMF indicates a reversible one-electron redox reaction. The complex has been shown to catalyze effectively the dismutation of superoxide (O-2(-)) in the riboflavin-methionine-nitro blue tetrazolium assay with an IC50 value of 2.93 muM. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：262 / 265

页数：4

共 26 条

[1]

[Anonymous], 1996, SAINT V4 SOFTWARE RE

[2]

[Anonymous], 1996, Duke University PCT Int. Appl., Patent No. [W09609053, 9609053]

[3]

[Anonymous], 1996, Duke University PCT Int. Appl., Patent No. [W09640223, 9640223]

[4] SUPEROXIDE DISMUTASE - IMPROVED ASSAYS AND AN ASSAY APPLICABLE TO ACRYLAMIDE GELS [J].

BEAUCHAM.C ;

FRIDOVIC.I .

ANALYTICAL BIOCHEMISTRY, 1971, 44 (01) :276-&

[5] beta-Amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger [J].

Bruce, AJ ;

Malfroy, B ;

Baudry, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2312-2316

[6] MANGANESE(III) AMIDE COMPLEXES AS A NEW CLASS OF CATALYST FOR EFFICIENT ALKENE EPOXIDATION [J].

CHE, CM ;

CHENG, WK .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1986, (18) :1443-1444

[7]

Ding J, 2001, CHIN J INORG CHEM, V17, P305

[8] Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies [J].

Doctrow, SR ;

Huffman, K ;

Marcus, CB ;

Tocco, G ;

Malfroy, E ;

Adinolfi, CA ;

Kruk, H ;

Baker, K ;

Lazarowych, N ;

Mascarenhas, J ;

Malfroyt, B .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (20) :4549-4558

[9]

DUKE U, 1993, Patent No. 5227405

[10]

EUKARION Inc., 1997, U.S. Patent, Patent No. [US5696109, 5696109]

← 1 2 3 →