Wide-field optical coherence tomography based microangiography for retinal imaging

被引：102

作者：

Zhang, Qinqin ^{[1
]}

Lee, Cecilia S. ^{[2
]}

Chao, Jennifer ^{[2
]}

Chen, Chieh-Li ^{[1
]}

Zhang, Thomas ^{[3
]}

Sharma, Utkarsh ^{[3
]}

Zhang, Anqi ^{[1
]}

Liu, Jin ^{[1
]}

Rezaei, Kasra ^{[2
]}

Pepple, Kathryn L. ^{[2
]}

Munsen, Richard ^{[2
]}

Kinyoun, James ^{[2
]}

Johnstone, Murray ^{[2
]}

Van Gelder, Russell N. ^{[2
]}

Wang, Ruikang K. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Bioengn, 3720 15th Ave NE, Seattle, WA 98195 USA

[2] Univ Washington, Dept Ophthalmol, 325 Ninth Ave, Seattle, WA 98104 USA

[3] Carl Zeiss Meditec Inc, Dublin, CA 94568 USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

POLYPOIDAL CHOROIDAL VASCULOPATHY; SOURCE OCT ANGIOGRAPHY; FLUORESCEIN ANGIOGRAPHY; NATURAL-HISTORY; DOMAIN OCT; NEOVASCULARIZATION; CLASSIFICATION; RANIBIZUMAB; THERAPY;

D O I：

10.1038/srep22017

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Optical coherence tomography angiography (OCTA) allows for the evaluation of functional retinal vascular networks without a need for contrast dyes. For sophisticated monitoring and diagnosis of retinal diseases, OCTA capable of providing wide-field and high definition images of retinal vasculature in a single image is desirable. We report OCTA with motion tracking through an auxiliary real-time line scan ophthalmoscope that is clinically feasible to image functional retinal vasculature in patients, with a coverage of more than 60 degrees of retina while still maintaining high definition and resolution. We demonstrate six illustrative cases with unprecedented details of vascular involvement in retinal diseases. In each case, OCTA yields images of the normal and diseased microvasculature at all levels of the retina, with higher resolution than observed with fluorescein angiography. Wide-field OCTA technology will be an important next step in augmenting the utility of OCT technology in clinical practice.

引用

页数：10

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