Cadherins as novel targets for anti-cancer therapy

被引：65

作者：

Blaschuk, Orest W. ^{[1
]}

Devemy, Emmanuelle ^{[1
]}

机构：

[1] McGill Univ, Urol Res Labs, Royal Victoria Hosp, Div Urol,Dept Surg, Montreal, PQ H3A 1A1, Canada

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2009年 / 625卷 / 1-3期

基金：

加拿大健康研究院;

关键词：

Cadherin; Blood vessel; Angiogenesis; Metastasis; CELL-CELL ADHESION; VASCULAR ENDOTHELIAL-CADHERIN; N-CADHERIN; MESENCHYMAL TRANSITION; PROSTATE-CANCER; BLOOD-VESSELS; VE-CADHERIN; TUMOR ANGIOGENESIS; GROWTH-FACTOR; EXPRESSION;

D O I：

10.1016/j.ejphar.2009.05.033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cell adhesion molecules N-, VE- and OB-cadherin have been implicated as regulators of tumor growth and metastasis. We discuss evidence that N- and VE-cadherin play a key role in promoting blood vessel formation and stability, processes which are essential for tumor growth. Secondly, we describe the potential involvement of N- and CB-cadherin in the metastatic process. Finally, studies concerning the effects of the N-cadherin antagonist designated ADH-1 on tumor growth are presented. Collectively, these observations suggest that antagonists of N, VE- and OB-cadherin would be useful as anti-cancer agents. (C) 2009 Elsevier B.V. All rights reserved.

引用

收藏

页码：195 / 198

页数：4

相关论文

共 61 条

[1] Endothelial/pericyte interactions [J].

Armulik, A ;

Abramsson, A ;

Betsholtz, C .

CIRCULATION RESEARCH, 2005, 97 (06) :512-523

[2] Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment [J].

Augustine, Christina K. ;

Yoshimoto, Yasunori ;

Gupta, Mukur ;

Zipfel, Patricia A. ;

Selim, M. Angelica ;

Febbo, Phillip ;

Pendergast, Ann Marie ;

Peters, William P. ;

Tyler, Douglas S. .

CANCER RESEARCH, 2008, 68 (10) :3777-3784

[3] Cellular abnormalities of blood vessels as targets in cancer [J].

Baluk, P ;

Hashizume, H ;

McDonald, DM .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (01) :102-111

[4] A phase I/II study of systemic ADH-1 in combination with isolated limb infusion with melphalan (ILI-M) in patients (pts) with locally advanced in-transit melanoma [J].

Beasley, G. ;

McMahon, N. ;

Sanders, G. ;

Zipfel, P. ;

Augustine, C. ;

Petros, W. ;

Padussis, J. ;

Ross, M. I. ;

Selim, A. ;

Peters, W. ;

Tyler, D. S. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)

[5] Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal [J].

Benjamin, LE ;

Golijanin, D ;

Itin, A ;

Pode, D ;

Keshet, E .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :159-165

[6]

Blaschuk O.W., 2000, U.S. Patent, Patent No. [6,031,072, 6031072]

[7]

Blaschuk O.W., 2006, VASCULAR TARGETED TH, P195, DOI [10.1002/0470035439.ch11, DOI 10.1002/0470035439.CH11]

[8] Endothelial cadherins and tumor angiogenesis [J].

Cavallaro, U ;

Liebner, S ;

Dejana, E .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (05) :659-667

[9] New signals from the invasive front [J].

Christofori, G .

NATURE, 2006, 441 (7092) :444-450

[10] Cadherin-11 promotes the metastasis of prostate cancer cells to bone [J].

Chu, Khoi ;

Cheng, Chien-Jui ;

Ye, Xiangcang ;

Lee, Yu-Chen ;

Zurita, Amado J. ;

Chen, Dung-Tsa ;

Yu-Lee, Li-Yuan ;

Zhang, Sui ;

Yeh, Edward T. ;

Hu, Mickey C-T. ;

Logothetis, Christopher J. ;

Lin, Sue-Hwa .

MOLECULAR CANCER RESEARCH, 2008, 6 (08) :1259-1267

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