Bifunctional reagents in organic synthesis

被引：178

作者：

Huang, Huan-Ming ^{[1
]}

Bellotti, Peter ^{[1
]}

Ma, Jiajia ^{[1
]}

Dalton, Toryn ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Westfalische Wilhelms Univ Munster, Organ Chem Inst, Munster, Germany

来源：

NATURE REVIEWS CHEMISTRY | 2021年 / 5卷 / 05期

关键词：

D O I：

10.1038/s41570-021-00266-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Developments in synthetic chemistry are increasingly driven by improvements in the selectivity and sustainability of transformations. Bifunctional reagents, either as dual coupling partners or as a coupling partner in combination with an activating species, offer an atom-economic approach to chemical complexity, while suppressing the formation of waste. These reagents are employed in organic synthesis thanks to their ability to form complex organic architectures and empower novel reaction pathways. This Review describes several key bifunctional reagents by showcasing selected cornerstone research areas and examples, including radical reactions, C-H functionalization, cross-coupling, organocatalysis and cyclization reactions.

引用

页码：301 / 321

页数：21

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