Partial thickness sclerectomy and intravitreal anti-VEGF therapy for intractable uveal effusion syndrome

被引：12

作者：

Guo, Jing ^{[1
,2
,3
]}

Cao, Xiaoguang ^{[1
,2
]}

Li, Xiaoxin ^{[1
,2
]}

机构：

[1] Peking Univ, Peoples Hosp, Dept Ophthalmol, Xizhimen South St 11, Beijing 100044, Peoples R China

[2] Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China

[3] Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Tongren Eye Ctr, Beijing, Peoples R China

来源：

INTERNATIONAL OPHTHALMOLOGY | 2019年 / 39卷 / 08期

关键词：

Intractable uveal effusion syndrome; Intravitreal anti-VEGF therapy; Aqueous VEGF concentration; FLUID;

D O I：

10.1007/s10792-018-0992-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose To report a case series of three patients with intractable uveal effusion syndrome (UES), treated with partial thickness sclerectomy and intravitreal anti-VEGF therapy. Methods Three patients with intractable UES were included. All patients underwent intravitreal anti-VEGF therapy to facilitate resolution of uveal effusion. The concentrations of IL-1 beta, IL-6, IL-8, IL-10, IL-12p70, TNF and VEGF in aqueous humor were measured. Results After the last intravitreal injection, all three eyes had total resolution of the chorioretinal detachment or subretinal fluid. One eye experienced improvement in visual acuity. All patients were free from recurrence during the follow-up period. Aqueous IL-6, IL-8 and VEGF concentrations were elevated in all cases. Conclusions Our current data provided the evidence that VEGF was increased in eyes with intractable UES and anti-VEGF therapy was effective, suggesting that partial thickness sclerectomy and intravitreal anti-VEGF therapy could be a new choice for intractable UES.

引用

页码：1885 / 1890

页数：6

共 11 条

[1] VASCULAR ENDOTHELIAL GROWTH-FACTOR IN OCULAR FLUID OF PATIENTS WITH DIABETIC-RETINOPATHY AND OTHER RETINAL DISORDERS [J].