Construction of magnetic-fluorescent bifunctional nanoparticles via miniemulsion polymerization for cell imaging

被引：12
作者：
Luo, Chenglin [1 ,2 ]
Yu, Bang [1 ,2 ]
Qi, Qi [1 ,2 ]
Mi, Yifang [1 ,2 ]
Cao, Zhihai [1 ,2 ]
Cui, Qinmin [3 ]
Zhao, Zujin [4 ]
机构：
[1] Zhejiang Sci Tech Univ, Minist Educ, Key Lab Adv Text Mat & Mfg Technol, Hangzhou 310018, Peoples R China
[2] Zhejiang Sci Tech Univ, Minist Educ, Engn Res Ctr Ecodyeing & Finishing Text, Hangzhou 310018, Peoples R China
[3] Hangzhou Med Coll, Sch Pharm, 481 Binwen Rd, Hangzhou 310053, Peoples R China
[4] South China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangdong Prov Key Lab Luminescence Mol Aggregate, Guangzhou 510640, Peoples R China
来源：
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2021年 / 613卷
基金：
中国国家自然科学基金;
关键词：
Miniemulsion polymerization; Fluorescence; Magnetic; Functional nanoparticles; Cell imaging; NANOCOMPOSITE PARTICLES; EFFICIENT PREPARATION; AIE; NANOPROBE; EMISSION; MRI;
D O I：
10.1016/j.colsurfa.2020.126062
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Magnetic-fluorescent bifunctional nanoparticles (NPs) have been widely used in biomedical applications. In this work, magnetic-fluorescent bifunctional NPs (P/Fe3O4/Nile Red NPs) were achieved via a facile miniemulsion polymerization. The morphologies and properties of the as-prepared P/Fe3O4/Nile Red NPs were systematically characterized. High-efficiency encapsulation of iron oxide (Fe3O4) and Nile Red in polymer matrix endowed the resultant P/Fe3O4/Nile Red NPs with prominent superparamagnetism and bright fluorescence. Furthermore, the cell viability experiment revealed the low cytotoxicity of P/Fe3O4/Nile Red NPs, indicating the P/Fe3O4/Nile Red NPs are suitable for cell imaging. This work provides a one-pot facile method to fabricate magnetic-fluorescent bifunctional NPs.
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页数：8
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