An overview on human polyomaviruses biology and related diseases

被引：9
作者：
Ciotti, Marco [1 ]
Prezioso, Carla [2 ]
Pietropaolo, Valeria [2 ]
机构：
[1] Polyclin Tor Vergata Fdn, Lab Virol, Viale Oxford 81, I-00133 Rome, Italy
[2] Sapienza Univ, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy
来源：
FUTURE VIROLOGY | 2019年 / 14卷 / 07期
关键词：
human diseases; immunocompromised patients; LT Ag; nephropathy; PML; polyomaviruses; skin diseases; ST-Ag; viral reactivation; VP1; protein; MERKEL-CELL POLYOMAVIRUS; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; CHRONIC LYMPHOCYTIC-LEUKEMIA; PERIPHERAL-BLOOD LEUKOCYTES; LOWER RESPIRATORY-TRACT; JC VIRUS-INFECTION; BK VIRUS; DNA-SEQUENCES; TRICHODYSPLASIA SPINULOSA; WU POLYOMAVIRUS;
D O I：
10.2217/fvl-2019-0050
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In recent years, the Polyomaviridae family grew rapidly, thanks to the introduction of high-throughput molecular techniques. To date, 14 polyomaviruses have been identified in humans but the association with human diseases has been established only for few of them. BKPyV has been associated with nephropathy in kidney transplant patients and hemorrhagic cystitis in hematopoietic stem cell transplant patients; JCPyV to progressive multifocal leukoencephalopathy, mainly in HIV-positive patients; Merkel cell polyomavirus to Merkel cell carcinoma; Trichodysplasia spinulosa polyomavirus to the rare skin disease Trichodysplasia spinulosa; human polyomaviruses 6 and 7 to pruritic rash. Immunocompromised patients are at risk of developing disease. Here, we summarized and discussed the scientific literature concerning the human polyomaviruses biology, seroprevalence and association with human diseases.
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收藏
页码：487 / 501
页数：15
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