Intercaudate nucleus ratio as a linear measure of brain atrophy in multiple sclerosis

被引：18

作者：

Caon, C ^{[1
]}

Zvartau-Hind, M ^{[1
]}

Ching, W ^{[1
]}

Lisak, RP ^{[1
]}

Tselis, AC ^{[1
]}

Khan, OA ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Neurol, Multiple Sclerosis Ctr, Detroit, MI 48201 USA

来源：

NEUROLOGY | 2003年 / 60卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000042094.91478.4A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Intercaudate nucleus ratio (ICR) is a linear measure of brain atrophy that does not require software application and is independent of image acquisition techniques. The authors examined the relationship between ICR and disability in 190 patients with MS. The results show that ICR correlates with Expanded Disability Status Scale score (r = 0.67; p = 0.0001) and disease duration (r = 0.32; p < 0.01). Intercaudate ratio appears to be a reliable and reproducible linear measure of brain atrophy and correlates with disability and disease duration in MS.

引用

页码：323 / 325

页数：3

共 7 条

[1] Bicaudate ratio as a magnetic resonance imaging marker of brain atrophy in multiple sclerosis [J].

Bermel, RA ;

Bakshi, R ;

Tjoa, C ;

Puli, SR ;

Jacobs, L .

ARCHIVES OF NEUROLOGY, 2002, 59 (02) :275-280

[2]

BUTZKUEVEN H, 2001, MULT SCLER S1, V7, pS40

[3] MRI techniques to monitor MS evolution - The present and the future [J].

Filippi, M ;

Grossman, RI .

NEUROLOGY, 2002, 58 (08) :1147-1153

[4] Progressive cerebral atrophy in multiple sclerosis - A serial MRI study [J].

Losseff, NA ;

Wang, L ;

Lai, HM ;

Yoo, DS ;

GawneCain, ML ;

McDonald, WI ;

Miller, DH ;

Thompson, AJ .

BRAIN, 1996, 119 :2009-2019

[5] Immunopathology of secondary-progressive multiple sclerosis [J].

Prineas, JW ;

Kwon, EE ;

Cho, ES ;

Sharer, LR ;

Barnett, MH ;

Oleszak, EL ;

Hoffman, B ;

Morgan, BP .

ANNALS OF NEUROLOGY, 2001, 50 (05) :646-657

[6] Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS [J].

Rudick, RA ;

Fisher, E ;

Lee, JC ;

Simon, J ;

Jacobs, L .

NEUROLOGY, 1999, 53 (08) :1698-1704

[7] A longitudinal study of brain atrophy in relapsing multiple sclerosis [J].

Simon, JH ;

Jacobs, LD ;

Campion, MK ;

Rudick, RA ;

Cookfair, DL ;

Herndon, RM ;

Richert, JR ;

Salazar, AM ;

Fischer, JS ;

Goodkin, DE ;

Simonian, N ;

Lajaunie, M ;

Miller, DE ;

Wende, K ;

Martens-Davidson, A ;

Kinkel, RP ;

Munschauer, FE ;

Brownscheidle, CM .

NEUROLOGY, 1999, 53 (01) :139-148

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