Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

被引：289

作者：

Ensan, Sherine ^{[1
]}

Li, Angela ^{[1
]}

Besla, Rickvinder ^{[2
]}

Degousee, Norbert ^{[3
]}

Cosme, Jake ^{[3
]}

Roufaiel, Mark ^{[3
]}

Shikatani, Eric A. ^{[2
]}

El-Maldizil, Mahmoud ^{[1
]}

Williams, Jesse W. ^{[4
]}

Robins, Lauren ^{[3
]}

Li, Cedric ^{[3
]}

Lewis, Bonnie ^{[3
]}

Yun, Tae Jin ^{[5
,6
]}

Lees, Jun Seong ^{[5
,6
]}

Wieghofer, Peter ^{[7
]}

Khattar, Ramzi ^{[3
]}

Farrokhil, Kaveh ^{[1
]}

Byrne, John ^{[15
]}

Ouzounian, Maral ^{[3
,15
]}

Zavitz, Caleb C. J. ^{[3
]}

Levy, Gary A. ^{[3
]}

Bauer, Carla M. T. ^{[8
]}

Libby, Peter ^{[9
]}

Husain, Mansoor ^{[2
,3
,15
]}

Swirski, Filip K. ^{[10
]}

Cheong, Cheolho

Prinz, Marco ^{[11
,12
]}

Hilgendorf, Ingo ^{[13
]}

Randolph, Gwendalyn J.

Epelman, Slava ^{[1
,3
,15
]}

Gramolini, Anthony O. ^{[3
,14
,15
]}

Cybulsky, Myron I. ^{[2
,3
,15
]}

Rubin, Barry B. ^{[3
,15
]}

Robbins, Clinton S. ^{[1
,2
,3
,15
]}

机构：

[1] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON, Canada

[4] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[5] Inst Rech Clin Montreal, Lab Cellular Physiol & Immunol, Montreal, PQ H2W 1R7, Canada

[6] Univ Freiburg, Inst Neuropathol, Hugstetter Str 55, D-79106 Freiburg, Germany

[7] Univ Freiburg, Fac Biol, Hugstetter Str 55, D-79106 Freiburg, Germany

[8] Hoffmann La Roche Inc, pRED, Pharma Res & Early Dev, DTA Inflammat, 340 Kingsland St, Nutley, NJ 07110 USA

[9] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

[10] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Syst Biol, Boston, MA USA

[11] Univ Freiburg, Inst Neuropathol, Hugstetter Str 55, D-79106 Freiburg, Germany

[12] Univ Freiburg, BIOSS Ctr Biol Signaling Studies, Hugstetter Str 55, D-79106 Freiburg, Germany

[13] Univ Freiburg, Dept Cardiol & Angiol 1, Hugstetter Str 55, D-79106 Freiburg, Germany

[14] Univ Toronto, Dept Physiol, Toronto, ON, Canada

[15] Univ Hlth Network, Peter Munk Cardiac Ctr, Toronto, ON, Canada

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 02期

基金：

加拿大健康研究院;

关键词：

DENDRITIC CELLS; YOLK-SAC; COMMITTED PROGENITORS; CARDIAC MACROPHAGES; FETAL MONOCYTES; STEADY-STATE; MICROGLIA; EXPRESSION; REVEALS; DIFFERENTIATION;

D O I：

10.1038/ni.3343

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Resident macrophages densely populate the normal arterial wall, yet their origins and the mechanisms that sustain them are poorly understood. Here we use gene-expression profiling to show that arterial macrophages constitute a distinct population among macrophages. Using multiple fate-mapping approaches, we show that arterial macrophages arise embryonically from CX3CR1(+) precursors and postnatally from bone marrow derived monocytes that colonize the tissue immediately after birth. In adulthood, proliferation (rather than monocyte recruitment) sustains arterial macrophages in the steady state and after severe depletion following sepsis. After infection, arterial macrophages return rapidly to functional homeostasis. Finally, survival of resident arterial macrophages depends on a CX3CR1-CX3CL1 axis within the vascular niche.

引用

页码：159 / 168

页数：10

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