Updates on Merkel Cell Carcinoma

被引：27

作者：

Emge, Drew A. ^{[1
]}

Cardones, Adela R. ^{[2
]}

机构：

[1] Duke Univ, Dept Dermatol, Durham, NC USA

[2] Duke Univ, Dept Dermatol, Duke Canc Inst, Durham VA Med Ctr, Durham, NC USA

来源：

DERMATOLOGIC CLINICS | 2019年 / 37卷 / 04期

关键词：

Merkel cell carcinoma; Cancer; Skin; Polyomavirus; LYMPH-NODE BIOPSY; MOHS MICROGRAPHIC SURGERY; WESTMEAD HOSPITAL EXPERIENCE; POPULATION-BASED COHORT; DEFINITIVE RADIOTHERAPY; RADIATION-THERAPY; ADJUVANT THERAPY; P63; EXPRESSION; T-CELLS; STAGE-I;

D O I：

10.1016/j.det.2019.06.002

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer associated with the Merkel cell polyoma virus. Its incidence and mortality are increasing. There have been many advances in the last several decades in the etiology, detection, and management of MCC, but much about its natural history and most effective treatment remains unknown. Surgical excision with margins of 1 to 2 cm remains first-line therapy for early-stage MCC, but robust evidence supporting immunotherapy for patients with advanced disease has led to recent approval of immune checkpoint inhibitors in the treatment of advanced MCC.

引用

页码：489 / +

页数：16

共 197 条

[1] Merkel Polyomavirus-Specific T Cells Fluctuate with Merkel Cell Carcinoma Burden and Express Therapeutically Targetable PD-1 and Tim-3 Exhaustion Markers [J].