共 50 条
Sleep-disordered breathing following acute stroke
被引:100
|作者:
Harbison, J
Ford, GA
James, OFW
Gibson, GJ
[1
]
机构:
[1] Freeman Rd Hosp, Dept Resp Med, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England
[2] Newcastle Univ, Dept Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
关键词:
D O I:
10.1093/qjmed/95.11.741
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background: The reported prevalence of sleep apnoea following stroke varies between 44% and 72%, but its course and relations are unclear. Aim: To determine the prevalence and course of sleep-disordered breathing in acute stroke in-patients, and its relation to age, stroke subtype, pre-stroke handicap and post-stroke outcome. Design: Prospective uncontrolled observational study. Methods: Paired respiratory sleep studies were performed at week 2 and week 6-9 following stroke. Pre- and post-stroke handicap (modified Rankin Score) and week 2 and week 6-9 disability (Barthel Score) and impairment (Scandinavian Neurological Stroke Score) were assessed. Pre-stroke sleepiness was determined by Epworth Score. Results: There were 68 patients in the week 2 study, and 50 in the week 6-8 study. Mean week 2 Apnoea Hypopnoea Index (AHI) was 30; 64 patients (94%) had an AHI greater than or equal to10. Mean AHI was higher in subjects with lacunar vs. cortical strokes (44 vs. 28, p<0.05), in subjects aged greater than or equal to65 years (32 vs. 21, p<0.05) and in those with greater pre-stroke handicap (modified Rankin Score 2 vs. <2) (41 vs. 27, p<0.05). In 50 paired studies, mean AHI fell from 31 to 24 (p<0.01) and the proportion with AHI greater than or equal to10 fell from 96% to 72%. Pre-stroke sleepiness was associated with post-stroke neurological impairment (r=-0.325, p<0.05) and disability (r=-0.377, p<0.05). Discussion: Sleep-disordered breathing improves in the first 6-9 weeks following stroke, but remains highly prevalent. Worse sleep-disordered breathing was observed following lacunar stroke, and in older subjects or those with pre-stroke handicap.
引用
收藏
页码:741 / 747
页数:7
相关论文