Vaccination with EtpA glycoprotein or flagellin protects against colonization with enterotoxigenic Escherichia coli in a murine model

被引：54
作者：
Roy, Koushik [1 ,2 ]
Hamilton, David
Ostmann, Marguerite M.
Fleckenstein, James M. [1 ,2 ]
机构：
[1] Univ Tennessee, Ctr Hlth Sci, Dept Med, Memphis, TN 38163 USA
[2] Vet Affairs Med Ctr, Memphis, TN 38119 USA
来源：
VACCINE | 2009年 / 27卷 / 34期
关键词：
Adhesins; Bacterial; Escherichia coli; Escherichia coli Vaccines; Diarrhea; Flagellin; HEAT-LABILE ENTEROTOXIN; ENTERIC INFECTIONS; IMMUNE-RESPONSES; DIARRHEA; STRAINS; ANTIGEN; GLYCOSYLATION; PATHOGENS; COMMUNITY; CHILDREN;
D O I：
10.1016/j.vaccine.2009.05.076
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Enterotoxigenic Escherichia coli (ETEC) remain a leading cause diarrheal illness, prompting a search for vaccine targets that led to the recent discovery of EtpA, a secreted adhesin of ETEC that acts by bridging flagella and host cells. In a murine model, immunization with recombinant EtpA glycoprotein inhibited colonization by two EtpA-producing human ETEC strains, H10407 and E24377A. In addition, vaccination with recombinant flagellin (serotype HI I) generated antibodies that specifically recognized the tips of flagella from E24377A expressing a heterologous flagellar serotype (H28) and afforded significant protection against colonization. EtpA and/or flagellin could be valuable subunit antigens in the formulation of a broadly protective ETEC vaccine. Published by Elsevier Ltd.
引用
收藏
页码：4601 / 4608
页数：8
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