Fetal-maternal exchange of multipotent stem/progenitor cells: microchimerism in diagnosis and disease

被引：39

作者：

Klonisch, Thomas ^{[1
,2
,3
]}

Drouin, Regen ^{[4
]}

机构：

[1] Univ Manitoba, Dept Human Anat, Winnipeg, MB, Canada

[2] Univ Manitoba, Dept Cell Sci, Winnipeg, MB, Canada

[3] Univ Manitoba, Fac Med, Winnipeg, MB, Canada

[4] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Pediat, Div Genet, Sherbrooke, PQ J1K 2R1, Canada

来源：

TRENDS IN MOLECULAR MEDICINE | 2009年 / 15卷 / 11期

基金：

加拿大自然科学与工程研究理事会;

关键词：

MOLECULAR CYTOGENETIC TECHNIQUES; NONINVASIVE PRENATAL-DIAGNOSIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; Y-CHROMOSOME MICROCHIMERISM; PRIMARY BILIARY-CIRRHOSIS; ALLOGENEIC BONE-MARROW; MESENCHYMAL STEM-CELLS; IN-SITU HYBRIDIZATION; T-CELLS; PERIPHERAL-BLOOD;

D O I：

10.1016/j.molmed.2009.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biological concept of microchimerism, the bidirectional trafficking and stable long-term persistence of small numbers of allogeneic (fetal and maternal) cells in a genetically different organ, has gained considerable attention. Microchimerism is a common phenomenon in many species, including humans, and microchimeric cells can modify immunological recognition or tolerance, affect the course and outcome of various diseases and demonstrate stem cell-like or regenerative potential. Here, we review current knowledge of the biology of microchimerism and show how long-term allogeneic coexistence within an organism can impact on existing paradigms in chronic disease, cancer biology, regenerative medicine and fetal-maternal immunology. We discuss diagnostic challenges, clinical applications and future research directions in this exciting and rapidly emerging field of allogeneic fetal-maternal cell exchange.

引用

页码：510 / 518

页数：9

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