Enantioselective total synthesis of 1-epi-pathylactone A

被引：25

作者：

Chanu, Angeline ^{[1
]}

Safir, Imad ^{[1
]}

Basak, Ramkrishna ^{[1
]}

Chiaroni, Angele ^{[1
]}

Arseniyadis, Simeon ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 07期

关键词：

D O I：

10.1021/ol070207y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first enantioselective total synthesis of 1-epi-pathylactone A, 3, has been accomplished using a PhI(OAc)(2)-mediated domino reaction as a key step. No diastereomeric separation was required throughout the whole synthetic scheme presented in this paper. Comparison of H-1 and C-13 NMR spectral data of the synthetic product with the reported spectral data of natural pathylactone A, coupled with an X-ray crystallographic analysis, led to the conclusion that the C1 configuration in the original paper was erroneously ascribed to (R).

引用

页码：1351 / 1354

页数：4

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